Metzen is married to Kat Hunter-Metzen, a former Blizzard employee and voice actress. She has voiced characters such as Zagara in StarCraft II and Valeera Sanguinar in Hearthstone. Their relationship is a vital part of his life.

Metzen and Kat have children together. He prioritizes his role as a father, and his desire to spend more time with his family was a primary reason for his initial retirement from Blizzard.