The modern combine harvester, also called a combine, is a machine designed to harvest a variety of cultivated seeds. Combine harvesters are one of the most economically important labour-saving inventions, significantly reducing the fraction of the population engaged in agriculture. Among the crops harvested with a combine are wheat, rice, oats, rye, barley, corn (maize), sorghum, millet, soybeans, flax (linseed), sunflowers and rapeseed (canola). The separated straw (consisting of stems and any remaining leaves with limited nutrients left in it) is then either chopped onto the field and ploughed back in, or laid out in rows, ready to be baled and used for bedding and cattle feed.

The name of the machine is derived from the fact that the harvester combined multiple separate harvesting operations – reaping, threshing or winnowing and gathering – into a single process around the start of the 20th century. A combine harvester still performs its functions according to those operating principles. The machine can easily be divided into four parts, namely: the intake mechanism, the threshing and separation system, the cleaning system, and finally the grain handling and storage system. Electronic monitoring assists the operator by providing an overview of the machine's operation, and the field's yield.

In 1826 in Scotland, the inventor Reverend Patrick Bell designed a reaper machine, which used the scissors principle of plant cutting (a principle that is used to this day). The Bell machine was pushed by horses. A few Bell machines were available in the United States. In 1835, in the United States, Hiram Moore built and patented the first combine harvester, which was capable of reaping, threshing and winnowing cereal grain. Early versions were pulled by horse, mule or ox teams. In 1835, Moore built a full-scale version with a length of 5.2 m (17 ft) and a cut width of 4.57 m (15 ft); by 1839, over 20 ha (50 acres) of crops were harvested. This combine harvester was pulled by 20 horses fully handled by farmhands. By around 1860, combine harvesters with a cutting, or swathe, width of several metres were used on American farms.

A parallel development in Australia saw the development of the stripper based on the Gallic stripper, by John Ridley and others in South Australia by 1843. The stripper only gathered the heads, leaving the stems in the field. The stripper and later headers had the advantage of fewer moving parts and only collecting heads, requiring less power to operate. Refinements by Hugh Victor McKay produced a commercially successful combine harvester in 1885, the Sunshine Header-Harvester.

Combines, some of them quite large, were drawn by mule or horse teams and used a bullwheel to provide power. Later, steam power was used, and George Stockton Berry integrated the combine with a steam engine using straw to heat the boiler. At the turn of the twentieth century, horse-drawn combines were starting to be used on the American plains and Idaho (often pulled by teams of twenty or more horses).

In 1911, the Holt Manufacturing Company of California, US produced a self-propelled harvester. In Australia in 1923, the patented Sunshine Auto Header was one of the first center-feeding self-propelled harvesters. In 1923 in Kansas, the Baldwin brothers and their Gleaner Manufacturing Company patented a self-propelled harvester that included several other modern improvements in grain handling. Both the Gleaner and the Sunshine used Fordson engines; early Gleaners used the entire Fordson chassis and driveline as a platform. In 1929, Alfredo Rotania of Argentina patented a self-propelled harvester. International Harvester started making horse-pulled combines in 1915. At the time, horse-powered binders and stand-alone threshing machines were more common. In the 1920s, Case Corporation and John Deere made combines, introducing tractor-pulled harvesters with a second engine aboard the combine to power its workings. The world economic collapse in the 1930s stopped farm equipment purchases, and for this reason, people largely retained the older method of harvesting. A few farms did invest and used Caterpillar tractors to move the outfits.

Tractor-drawn combines (also called pull-type combines) became common after World War II as many farms began to use tractors. An example was the All-Crop Harvester series. These combines used a shaker to separate the grain from the chaff and straw-walkers (grates with small teeth on an eccentric shaft) to eject the straw while retaining the grain. Early tractor-drawn combines were usually powered by a separate gasoline engine, while later models were PTO-powered, via a shaft transferring tractor engine power to operate the combine. These machines either put the harvested crop into bags that were then loaded onto a wagon or truck, or had a small bin that stored the grain until it was transferred via a chute.

In the U.S., Allis-Chalmers, Massey-Harris, International Harvester, Gleaner Manufacturing Company, John Deere, and Minneapolis Moline are past or present major combine producers. In 1937, the Australian-born Thomas Carroll, working for Massey-Harris in Canada, perfected a self-propelled model and in 1940, a lighter-weight model began to be marketed widely by the company. Lyle Yost invented an auger that would lift grain out of a combine in 1947, making unloading grain much easier and further from the combine. In 1952 Claeys launched the first self-propelled combine harvester in Europe; in 1953, the European manufacturer Claas developed a self-propelled combine harvester named 'Hercules', it could harvest up to 5 tons of wheat a day. This newer kind of combine is still in use and is powered by diesel or gasoline engines. Until the self-cleaning rotary screen was invented in the mid-1960s combine engines suffered from overheating as the chaff spewed out when harvesting small grains would clog radiators, blocking the airflow needed for cooling.