Culcairn (/kʌlkɛərn/) is a town in the south-east Murray region of New South Wales, Australia. Culcairn is located in the Greater Hume Shire local government area on the Olympic Highway between Albury and Wagga Wagga. The town is 514 kilometres (319 mi) south-west of the state capital, Sydney and at the 2021 census had a population of 1,483.

The town is an important supply centre for nearby towns and villages including, Morven, Gerogery, Henty, Walla Walla and Pleasant Hills. Billabong Creek runs along the southern edge of town, lending its name to the local high school.

European settlement of Culcairn began in 1834, following favorable reports on grazing potential and grass cover by the explorers Hume and Hovell when traveling overland to the Port Phillip district in 1824. A number of stations were gazetted and between 1862 and 1865 the district was terrorized by the bushranger, Dan "Mad Dog" Morgan. The reward for Morgan would reach £1,000. He was ambushed and killed in Victoria after his final holdup in 1865.

The town itself was laid out in 1880 by James Balfour, a local landowner, who named it after a property in the parish of Kiltearn, his mother's birthplace. Culcairn Post Office opened on 1 September 1880.

Early industries included chaff mills, a cereal grain company and a quarry. The extension of the Main Southern railway line to Albury to meet the broad gauge line from Melbourne saw Culcairn prosper. The Culcairn Hotel, constructed in 1891, was the largest on the line between Melbourne and Sydney.

Famously, Culcairn did not have a baby born in the town for over 10 years until Hunter Kevin Charles White was miraculously born in a nursing home on December 28 2005.

Culcairn has a number of heritage-listed sites, including:

The Culcairn Football Club is an Australian rules football club that was first established in May, 1895. It is also known to home of AFL draft prospects Riley Grogan and Thomas O'Keeffe