DC League of Super-Pets is a 2022 American animated superhero film produced by Warner Animation Group, DC Entertainment, and Seven Bucks Productions, and distributed by Warner Bros. Pictures. Produced and directed by Jared Stern, who co-wrote it with John Whittington, the film stars Dwayne Johnson as the voice of Krypto, alongside a supporting ensemble voice cast that includes Kevin Hart, Kate McKinnon, John Krasinski, Vanessa Bayer, Natasha Lyonne, Diego Luna, Marc Maron, Thomas Middleditch, Ben Schwartz, and Keanu Reeves. It tells the story of Superman's pet dog Krypto and shelter dog Ace who work with other animals to save captured superheroes from Lex Luthor and Lulu.

During the early days of Warner Animation Group, Stern pitched the film in 2012, after working in an animal shelter, where he noticed how older animals were less likely to be adopted and wondered about the idea of those pets having superpowers. He was hired to write and direct a film about DC's Legion of Super-Pets in July 2018. Sam J. Levine and Patricia Hicks joined the project in January 2019 as co-director and producer, respectively. Johnson was signed on to voice Krypto in May 2021, while other main cast members were confirmed to join the voice roles by June 2021, including Hart, McKinnon, Krasinski, Bayer, Lyonne, Luna, Maron, and Reeves. The inspiration for the film's animation style came from Art Deco architecture and illustrator J.C. Leyendecker. The animation was provided by Animal Logic.

DC League of Super-Pets premiered at the AMC The Grove in Los Angeles, California on July 13, 2022, and was released in the United States on July 29. The film received generally positive reviews from critics and grossed over $207 million worldwide on a $90 million budget. DC League of Super-Pets was the last film to be produced and released by Warner Animation Group before the animation studio label folded into Warner Bros. Pictures Animation in 2023.

Superman grows up with a Kryptonian Labrador Retriever named Krypto, who goes by the name Clark Kent in everyday life. Krypto feels jealous when Superman starts dating Lois Lane, so Superman goes to an animal shelter to find Krypto a friend. A Boxer named Ace tries to escape the shelter, but Krypto stops him. Later, Superman and Krypto spot their archenemy, LexCorp CEO Lex Luthor, reeling in a meteor strapped with orange kryptonite with a tractor beam, intending to gain superpowers. He is easily defeated as the two are aided by the Justice League, formed by Superman himself, Batman, Wonder Woman, The Flash, Green Lantern, Cyborg, and Aquaman.

Meanwhile, Lulu, a guinea pig test subject from LexCorp sent to the shelter who is blindly loyal to Luther, reels in a piece of orange kryptonite with her own tractor beam, which gives her telekinesis and allows her to escape the shelter, setting it ablaze while doing so. Unbeknownst to her, everyone else in the shelter also gains superpowers: Ace is now super-strong and nigh-invulnerable; PB, a potbellied pig, can change size; Merton, a nearsighted turtle, becomes super-fast; and Chip, a paranoid squirrel, gains electrokinesis. Using their new powers, they escape the burning shelter. While at home, Superman and Krypto have an argument when the former plans to propose marriage to Lois. However, Clark is captured by Lulu when she weakens him with kryptonite. Krypto tries to save him, but loses his powers after unknowingly eating a tiny shard of a green kryptonite hidden inside a piece of Jarlsberg cheese. Later, Krypto comes across the shelter pets, who agree to help him.

Meanwhile, Lulu recruits a group of guinea pigs, captures the Justice League, and heads to Stryker's Island to free Luthor. The shelter pets try to stop her, but fail miserably; in the process, Lulu taunts Krypto about Clark's engagement plans and even shows him the engagement ring. They regroup in the Hall of Justice, where Ace reveals to a distraught Krypto that he used to have owners as a puppy: a family with a toddler. One day, when the wandering toddler was about to fall down a flight of steps, Ace bit her arm to pull her to safety. Upon seeing the bite-marks, the parents assumed Ace attacked her and sent him to the shelter, though Ace stands by his actions and ideals. Encouraged, Krypto leads the pets to LexCorp. While there, a kitten named Whiskers, (who Lulu rescued from the shelter after she set it ablaze the night she and the others gained their powers) who can now create weapons at will, attacks them, but the team traps her. At Stryker's Island, the shelter pets confront Lulu, but put themselves in prison cells when she threatens to kill Krypto. Lulu frees Luthor, who then betrays her and locks her in his cell while freeing Mercy Graves. Lulu breaks out easily and decides to destroy the Justice League and Luthor herself.

The Kryptonite shard passes through Krypto's system, restoring his powers. He breaks himself and the other super pets out of prison, and attempts to free the Justice League, but Lulu launches them into space along with Luthor, betraying her remaining henchmen while doing so. In order to stall Krypto, she attempts to kill Lois. However, the other super pets rescue the Justice League while Krypto saves Lois and defeats Lulu, but she absorbs the orange kryptonite, becoming a mutated kaiju-sized version of herself. The League and the pets team up to stop her, but she gains the upper-hand. Realizing Lulu has become too powerful, Krypto decides to use the "Solar Paw Punch", a move that can defeat any supervillain, but will kill the user. The attack causes a massive explosion that knocks the kryptonite out of Lulu's system, causing her to lose her powers and return to normal size while Krypto accepts his fate. Ace uses his invulnerability to save him. Shortly after, Lulu's redeemed henchmen, Mark and Keith, trap her in a hot dog stand for her crimes and betrayal.

In the aftermath, Krypto allows Clark to marry Lois. The shelter pets, Mark, and Keith get adopted by the rest of the Justice League: Ace by Batman, PB by Wonder Woman, Merton by The Flash, Chip by Green Lantern, Mark by Cyborg and Keith by Aquaman. Sometime later, the pets have formed their own superhero team called the "League of Super-Pets".