David Hugh Mackenzie (born 10 May 1966) is a Scottish film director and co-founder of the Glasgow-based production company Sigma Films. He has made ten feature films including Young Adam (2003), Hallam Foe (2007), Perfect Sense (2011) and Starred Up (2013). In 2016, Mackenzie's film Hell or High Water premiered at Cannes and was theatrically released in the United States in August. The same year he executive produced Damnation, a TV pilot for Universal and USA Network. Mackenzie also directed Outlaw King (2018), a historical film for Netflix. Mackenzie and his films have been described as not fitting neatly into any particular genre or type.

After studying at Duncan of Jordanstone College of Art and Design in Dundee, Mackenzie began his directorial career with a series of well-regarded shorts, the first being Dirty Diamonds (1994). After that came California Sunshine (1997), Somersault (1999) and Marcie's Dowry (2000). All were nominated for and won numerous awards internationally.

Mackenzie's debut feature film is titled The Last Great Wilderness (2002). His brother, actor Alastair Mackenzie, plays a character looking to exact revenge by burning down his wife's lover's house in the Highlands. The film begins as a comedy gangster thriller, then wanders into horror film territory before subverting all expectations and delivering something altogether different instead. It premiered at TIFF in 2002.

He followed this with his acclaimed adaptation of Scots beat writer Alexander Trocchi's cult novel, Young Adam (2003). It features Ewan McGregor as a young drifter working on a river barge as he disrupts his employers' lives while hiding the fact that he knows more about a dead woman found in the river than he admits. Tilda Swinton, Peter Mullan and Emily Mortimer also star. The film premiered in the Un Certain Regard, Cannes 2003, and played TIFF and Telluride, winning Best Film and Best Director at the 2004 BAFTA Scotland awards. Tilda Swinton and Ewan McGregor both won Scottish BAFTAs for their performances. The film also won the Michael Powell Award for Best British Feature at EIFF, and British Newcomer of the Year at the London Critics Circle Awards and was nominated for four BIFA nominations and several European Film Academy Awards.

In 2005 Mackenzie directed Asylum, adapted from Patrick McGrath's book and starring Natasha Richardson, Sir Ian McKellen, Hugh Bonneville and Marton Coskas. It follows Richardson's character as she becomes very curious about one of her psychiatrist husband's inmates, a man who was found guilty in the murder and disfigurement of his former wife. It was nominated for Berlin's Golden Bear and won the Prize of the Guild of German Art House Cinemas at the 2005 Berlin International Film Festival.

Next, Mackenzie directed the highly regarded Hallam Foe, starring Jamie Bell and Sophia Myles. The film is adapted from the book by Peter Jinks and follows the voyeuristic title character as he runs away to Edinburgh and becomes transfixed by a beautiful woman who looks uncannily like his late mother. Again, this film won many awards including a Silver Bear in Berlin 2007, the Golden Hitchcock and Kodak Award for Cinematography at the Dinard Festival 2007, and the 2008 National Board of Review Award for Top Independent Film, as well as numerous other awards.

In 2009 he directed the sex satire Spread, which marked Mackenzie's first feature in the US. The film follows Ashton Kutcher's LA gigolo as he begins living with a rich older client played by Anne Heche. Spread had its premiere at Sundance.

Mackenzie followed this by returning to Glasgow to make sci-fi romance Perfect Sense (2011). The film follows a burgeoning romance between Ewan McGregor and Eva Green against the backdrop of a global pandemic of people losing their senses one by one. The film premiered at Sundance Film Festival in 2011 and picked up awards at film festivals around the world including Edinburgh, Bratislava and Philadelphia International Film Festivals.