Deoxyhypusine monooxygenase

In enzymology, a deoxyhypusine monooxygenase (EC 1.14.99.29) is an enzyme that catalyzes the chemical reaction

protein N⁶-(4-aminobutyl)-L-lysine + AH₂ + O₂ ${\displaystyle \rightleftharpoons }$ protein N⁶-[(R)-4-amino-2-hydroxybutyl]-L-lysine + A + H₂O

The 3 substrates of this enzyme are a protein-bound N⁶-(4-aminobutyl)-L-lysine, an electron acceptor AH₂, and O₂, and its 3 products are protein-bound N⁶-[(R)-4-amino-2-hydroxybutyl]-L-lysine, the reduction product A, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O₂ as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derive from O miscellaneous. The systematic name of this enzyme class is deoxyhypusine,hydrogen-donor:oxygen oxidoreductase (2-hydroxylating). Other names in common use include deoxyhypusine hydroxylase, and deoxyhypusine dioxygenase.

The HUGO symbol for human gene and protein is DOHH, the full name is deoxyhypusine hydroxylase, and there are orthologs in other mammals.^[1] The orthologs have the same symbol, except for rodents, there the symbol is Dohh. The difference in case is just a meaningless historical artifact.

• Abbruzzese A, Park MH, Folk JE (1986). "Deoxyhypusine hydroxylase from rat testis. Partial purification and characterization". J. Biol. Chem. 261 (7): 3085–9. doi:10.1016/S0021-9258(17)35750-2. PMID 3949761.

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