The Dominickers are a small biracial or triracial ethnic group that was once centered in the Florida Panhandle county of Holmes, in a corner of the southern part of the county west of the Choctawhatchee River, near the town of Ponce de Leon. The group was classified in 1950 as one of the "reputed Indian-White-Negro racial isolates of the Eastern United States" by the United States Census Bureau.

Few facts are known about their origins, and little has been published about this group.

The first known mention in print of the Dominickers is an article in Florida: A Guide to the Southernmost State, published by the Federal Writers' Project in 1939. The article "Ponce de Leon" identifies the Dominickers as being mixed-race descendants of the widow of a pre-Civil War plantation owner and one of her black slaves, by whom she had five children. (A separate oral tradition has it that the slave was the mixed-race or mulatto half-brother of the woman's deceased husband, but this has not been verified. In that account the half-brother's mother had been enslaved.)

The unsigned article said that numerous descendants still lived in the area at the time of writing. Their children were required to attend a segregated school (as required by Florida's Jim Crow laws). Dominickers were not accepted as social equals by the white community, but they kept themselves apart from the main black community. The Dominickers formed a small middle layer of Holmes County society separate from both whites and blacks (somewhat analogous to the status of free people of color, the Louisiana Creoles before the United States purchase of the Louisiana Territory).

According to the article, the appearance of Dominickers varied from very fair (white) to "Negroid" (black), even among the siblings of a single family. The nickname "Dominickers", taken as pejorative, was said to come from a local man in a divorce case describing his estranged wife as "black and white, like an old Dominicker chicken." Another account says the description was applied, instead, to the man with whom she was living after she left her husband.

Two unpublished typescripts prepared for the FWP Florida guidebook, but not included in it, are archived at the University of Florida library in Gainesville. They were likely sources or drafts of the published article.^{[citation needed]}

These typescripts go into further detail than the published article on the appearance and behavior of the Dominickers, saying that the local people described them as "sensitive, treacherous, and vindictive" and "pathetically ignorant." The men are described as "big and burly looking," known for their skill at breaking horses and making moonshine whiskey. The women were described as "low in stature, fat, and shapeless," wearing loose clothing and going barefoot all the time.

One article notes that Dominickers were "treated with the same courtesy that a Negro receives—never served at a public fountain nor introduced to a white person." A few Dominicker children were allowed to attend the white high school in Westville, but they were "never allowed to actually graduate."