The Duke or Duchess of Durazzo (Albanian: Duka i Durrësit, Dukesha e Durrësit) also known as Duke or Duchess of Durrës was a noble title used by the rulers of Durrës (city in modern-day Albania) during the middle ages. The title was originally established by the House of Anjou-Durazzo following the decline of the Kingdom of Albania, and it was later adopted by the House of Thopia, one of the major noble families in medieval Albania.

The last holder of the title was the Albanian prince Gjergj Thopia, who was compelled to cede the city of Durrës to the Venetians in 1392.

The modern-day descendants of the Dukes and Duchesses of Durazzo no longer hold any social or political power within the city.

During the late 11th and the 12th centuries, the city of Durazzo and its province (the "Theme of Dyrrhachium"), had risen to assume great strategic importance to the Byzantine Empire. The city was the "key of Albania", the western terminus of the Via Egnatia and the main point of entry for trade, but also for the Norman invasions, from Italy, and was ideally placed to control the actions of the Slavic rulers of the western Balkans.

After the sack of Constantinople by the Fourth Crusade and the dissolution of the Byzantine Empire in 1204, the city was left unclaimed. In the partition treaty among the Crusaders, the Republic of Venice had secured recognition of her claims on the westernmost Byzantine provinces, which were crucial in view of the vital Venetian interests in the Adriatic Sea. However, the claim had to be quickly enforced, lest others, and chiefly the Venetians' main rivals, the Genoese, occupy it first. As a result, in the summer of 1205, the Venetian fleet carrying the new Latin Patriarch of Constantinople to his see, also attacked and captured Durazzo and Corfu.

At Durazzo, the Venetians met little opposition and one of the captains, Marino Vallaresso, was appointed governor of Durazzo with the title of duke, a sign of the value the Venetians placed in their new possession. For the same reason they insisted on the appointment of the city's Roman Catholic archbishop, who replaced the previous Greek Orthodox prelate, directly by Venice, without the involvement of the Pope.

Although the Venetians had also laid claim to the mainland region of Epirus, they did not move to establish control there. Consequently, the area came under the rule of a Byzantine Greek aristocrat, Michael I Komnenos Doukas, who established his own principality there, the Despotate of Epirus. Doukas' power grew quickly, and he soon controlled all the mainland between the Venetian Duchy of Durazzo and the Corinthian Gulf in the south. Unable and unwilling to undertake the effort necessary confront him, the Venetians preferred to conclude a compromise treaty with Doukas in June 1210, which recognized him as ruler of Epirus, but as the nominal vassal of Venice, which had claimed this territory since 1204.

This treaty was expedient for Doukas, but did not mean the abandonment of his own designs on Durazzo: in 1213, his forces captured the city, ended the Venetian presence, and restored a Greek Orthodox archbishop to the local see. Soon after, Doukas' forces also took Corfu, and moved to extend his rule over Albania and western Macedonia, capturing the lordship of Krujë and pushing up to the borders of Zeta.