Echovirus is a polyphyletic group of viruses associated with enteric disease in humans. The name is derived from "enteric cytopathic human orphan virus". These viruses were originally not associated with disease, but many have since been identified as disease-causing agents. The term "echovirus" was used in the scientific names of numerous species, but all echoviruses are now recognized as strains of various species, most of which are in the family Picornaviridae.

Thirty-four echoviruses are known:

When one is infected with echovirus, symptoms are rare but can occur. When symptoms occur, they often include a cough, rash, and influenza-like symptoms. Rare symptoms include viral meningitis, which affects the brain and spinal cord.

Echovirus infection mostly clears up on its own. Doctors may give an immune-system treatment called IVIG, which can help those with weak immune systems. No medicines are known to help against the virus.