Various people and groups assert that U.S. president Donald Trump engaged in impeachable activity both before and during his first presidency, and talk of impeachment began before he took office. Grounds asserted for impeachment have included possible violations of the Foreign Emoluments Clause of the Constitution by accepting payments from foreign dignitaries; alleged collusion with Russia during the campaign for the 2016 United States presidential election; alleged obstruction of justice with respect to investigation of the collusion claim; and accusations of "Associating the Presidency with White Nationalism, Neo-Nazism and Hatred", which formed the basis of a resolution for impeachment brought on December 6, 2017.

The first formal impeachment efforts were initiated by two Democratic representatives (Al Green and Brad Sherman) in 2017, the first year of his presidency. Since the Republicans controlled both the House and the Senate during 2017 and 2018, the likelihood of impeachment during that period was considered by all to be low. A December 2017 resolution of impeachment failed in the House by a 58–364 margin. The Democrats gained control of the House in 2019 and launched multiple investigations into Trump's actions and finances. Speaker Nancy Pelosi initially resisted calls for impeachment. In May 2019, Pelosi indicated that Trump's continued actions, which she characterized as obstruction of justice and refusal to honor congressional subpoenas, might make an impeachment inquiry necessary. An increasing number of House Democrats and one Republican were requesting such an inquiry.

On September 24, 2019, Pelosi announced that six committees would undertake a formal impeachment inquiry after reports about controversial interactions between Trump and the country of Ukraine. This inquiry resulted in Trump's first impeachment on December 18, 2019.

In January 2021, during the final weeks of Trump's first term, a renewed effort was made to remove him from office following his efforts to overturn his loss in the 2020 presidential election by baselessly asserting voter fraud, which resulted in the Trump-Raffensperger phone call and the United States Capitol attack. This effort resulted in Trump's second impeachment on January 13, 2021.

On April 29, 2025, approximately 3 months after the beginning of Trump's second term, Shri Thanedar announced his intention to impeach Trump, and on May 14, 2025, brought forward 7 articles of impeachment, arguing Trump has committed obstruction of justice, bribery and corruption. However, the motion has been condemned by other congressional Democrats.

On May 15, 2025, Al Green submitted articles of impeachment, in House Resolution 415.

In June 2025, Elon Musk called for Trump to be impeached when he engaged in a public feud with Trump.

In December 2016, Democratic senators Elizabeth Warren, Dick Durbin, Chris Coons, Ben Cardin, and Jeff Merkley introduced a bill that would require the president of the United States to divest any assets that could raise a conflict of interest, including a statement that failure to divest such assets would constitute high crimes and misdemeanors "under the impeachment clause of the U.S. Constitution". Vanity Fair characterized this as a preemptive effort to lay the groundwork for a future impeachment argument. Concerns had previously been expressed that Trump's extensive business and real estate dealings, especially with respect to government agencies in other countries, may violate the Foreign Emoluments Clause of the Constitution, sparking debate as to whether that is the case.