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Fluorodopa (18F)
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| Clinical data | |
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| Trade names | Fluorodopa F18 |
| Other names | 6-fluoro-L-DOPA, FDOPA |
| AHFS/Drugs.com | Micromedex Detailed Consumer Information |
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| Routes of administration | Intravenous |
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| Formula | C9H10FNO4 |
| Molar mass | 215.180 g·mol−1 |
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Fluorodopa (18F), also known as FDOPA, is a fluorinated form of L-DOPA primarily synthesized as its fluorine-18 isotopologue for use as a radiotracer in positron emission tomography (PET).[2]
The most common side effects are injection site pain.[1]
Medical uses
[edit]Fluorodopa (18F) is indicated for use in positron emission tomography (PET) to visualize dopaminergic nerve terminals in the striatum for the evaluation of adults with suspected Parkinsonian syndromes.[1]
History
[edit]In October 2019, Fluorodopa (18F) was approved in the United States for the visual detection of certain nerve cells in adults with suspected Parkinsonian syndromes.[3][4]
The US Food and Drug Administration approved Fluorodopa F 18 based on evidence from one clinical trial of 56 participants with suspected Parkinsonian syndromes.[3] The trial was conducted at one clinical site in the United States.[3]
References
[edit]- ^ a b c "Fluorodopa F18 injection". DailyMed. 12 October 2019. Retrieved 26 April 2020.
- ^ Deng WP, Wong KA, Kirk KL (June 2002). "Convenient syntheses of 2-, 5- and 6-fluoro- and 2,6-difluoro-L-DOPA". Tetrahedron: Asymmetry. 13 (11): 1135–1140. doi:10.1016/S0957-4166(02)00321-X.
- ^ a b c "Drug Trials Snapshots: Fluorodopa F 18". U.S. Food and Drug Administration (FDA). 27 November 2019. Archived from the original on 27 November 2019. Retrieved 27 November 2019.
This article incorporates text from this source, which is in the public domain.
- ^ "Drug Approval Package: Fluorodopa F18". U.S. Food and Drug Administration (FDA). 20 November 2019. Archived from the original on 27 November 2019. Retrieved 26 November 2019. This article incorporates text from this source, which is in the public domain.
