Fallypride

Fallypride (¹⁸F)
Clinical data
Pregnancy; category	N/A;
ATC code	none;
Legal status
Legal status	Research compound;
Identifiers
	IUPAC name 5-(3-18F-fluoropropyl)-2,3-dimethoxy-N-[(2S)-1-prop-2-enylpyrrolidin-2-yl]methyl]benzamide;
CAS Number	166173-78-0;
PubChem CID	10021692;
DrugBank	DB15167;
ChemSpider	8197265;
UNII	G9FWZ369GX;
ChEMBL	ChEMBL392158;
CompTox Dashboard (EPA)	DTXSID30937173 ;
Chemical and physical data
Formula	C20H29FN2O3
Molar mass	364.461 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES COC1=CC(=CC(=C1OC)C(=O)NC[C@@H]2CCCN2CC=C)CCCF;
	InChI InChI=1S/C20H29FN2O3/c1-4-10-23-11-6-8-16(23)14-22-20(24)17-12-15(7-5-9-21)13-18(25-2)19(17)26-3/h4,12-13,16H,1,5-11,14H2,2-3H3,(H,22,24)/t16-/m0/s1; Key:OABRYNHZQBZDMG-INIZCTEOSA-N;

Fallypride is a high-affinity dopamine D2/D3 receptor antagonist used in medical research,^[1] usually in the form of fallypride (¹⁸F) as a positron emission tomography (PET) radiotracer in human studies.^[2]^[3]

References

^ Mukherjee J, Yang ZY, Das MK, Brown T (April 1995). "Fluorinated benzamide neuroleptics – III. Development of (S)-N-[(1-allyl-2-pyrrolidinyl)methyl]-5-(3-[18F]fluoropropyl)-2, 3-dimethoxybenzamide as an improved dopamine D-2 receptor tracer". Nuclear Medicine and Biology. 22 (3): 283–96. doi:10.1016/0969-8051(94)00117-3. PMID 7627142.
^ Mukherjee J, Christian BT, Dunigan KA, Shi B, Narayanan TK, Satter M, Mantil J (December 2002). "Brain imaging of 18F-fallypride in normal volunteers: blood analysis, distribution, test-retest studies, and preliminary assessment of sensitivity to aging effects on dopamine D-2/D-3 receptors". Synapse. 46 (3): 170–88. doi:10.1002/syn.10128. PMID 12325044. S2CID 24852944.
^ Rieck RW, Ansari MS, Whetsell WO, Deutch AY, Kessler RM (February 2004). "Distribution of dopamine D2-like receptors in the human thalamus: autoradiographic and PET studies". Neuropsychopharmacology. 29 (2): 362–72. doi:10.1038/sj.npp.1300336. PMID 14627996.

External links

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[1] Mukherjee J, Yang ZY, Das MK, Brown T (April 1995). "Fluorinated benzamide neuroleptics – III. Development of (S)-N-[(1-allyl-2-pyrrolidinyl)methyl]-5-(3-[18F]fluoropropyl)-2, 3-dimethoxybenzamide as an improved dopamine D-2 receptor tracer". Nuclear Medicine and Biology. 22 (3): 283–96. doi:10.1016/0969-8051(94)00117-3. PMID 7627142.

[2] Mukherjee J, Christian BT, Dunigan KA, Shi B, Narayanan TK, Satter M, Mantil J (December 2002). "Brain imaging of 18F-fallypride in normal volunteers: blood analysis, distribution, test-retest studies, and preliminary assessment of sensitivity to aging effects on dopamine D-2/D-3 receptors". Synapse. 46 (3): 170–88. doi:10.1002/syn.10128. PMID 12325044. S2CID 24852944.

[3] Rieck RW, Ansari MS, Whetsell WO, Deutch AY, Kessler RM (February 2004). "Distribution of dopamine D2-like receptors in the human thalamus: autoradiographic and PET studies". Neuropsychopharmacology. 29 (2): 362–72. doi:10.1038/sj.npp.1300336. PMID 14627996.

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