Frances Lake is a lake of Yukon, Canada. With an area of 9,941 hectares (24,560 acres; 38.38 sq mi) it is the largest lake in southeast Yukon and the largest in territory that does not flow into the Yukon River, instead draining to the Frances River and then the Beaufort Sea via the Liard and Mackenzie rivers. The lake lies at an elevation of 734 m (2,408 ft) has an average depth of 31 m (102 ft) and a maximum depth of 93 m (305 ft).

Several rivers and creeks flow into Frances Lake, forming extensive deltas. The lake and surrounding area was featured in Anton Money's 1975 autobiographical book This Was the North and one of the creeks is named Money Creek after this early settler to the area.

Hour Lake, at an altitude of 890 m (2,920 ft), is a weather station located approximately 10 km (6.2 mi) to the south of Frances Lake. The region, typically for the Yukon, has a subarctic climate (Köppen Dfc) characterised by short, mild summers and long, frigid winters, although there is much greater precipitation and snowfall than more northerly parts of the Territory due to being closer to Pacific Ocean moisture.