Frank Leroy Chance (September 9, 1877 – September 15, 1924) was an American professional baseball player. A first baseman, Chance played in Major League Baseball for the Chicago Cubs and New York Yankees from 1898 through 1914. He also served as manager of the Cubs, Yankees, and Boston Red Sox.

Discovered by the Cubs as he played semi-professional baseball while attending college, Chance debuted with the Cubs in 1898, serving as a part-time player. In 1903, Chance became the Cubs' regular first baseman, and in 1905, he succeeded Frank Selee as the team's manager. Chance led the Cubs to 100 wins in 1906, 1907, 1909, and 1910, becoming the first manager to compile four 100-win seasons (only eight other managers have accomplished the feat in MLB history), with no manager, other than Chance, leading a team to 100 wins four times in five seasons. They would win four National League championships in that span and won the World Series in 1907 and 1908. With Joe Tinker and Johnny Evers, Chance formed a strong double play combination, which was immortalized as "Tinker-to-Evers-to-Chance" in "Baseball's Sad Lexicon".

Let go by the Cubs after the 1912 season, Chance signed with the Yankees, serving as a player–manager for two seasons. He joined the Los Angeles Angels of the Pacific Coast League as a player–manager, returning to MLB in 1923 as manager of the Red Sox. Chance was named the manager of the Chicago White Sox in 1924, but never took control of the team as he became ill. He died later that year.

Noted for his leadership abilities, Chance earned the nickname "Peerless Leader." He is the all-time leader in managerial winning percentage in Cubs history. Chance was elected to the Baseball Hall of Fame in the 1946 balloting by the Veterans Committee, along with Tinker and Evers. He was inducted into the Fresno County Athletic Hall of Fame's first class, in 1959.

Chance was born in Salida, California, in Stanislaus County, on September 9, 1877. His family was of English and Scottish descent. He was raised in Fresno, California and attended Fresno High School. His father was president of the first national bank in Fresno.

Chance enrolled at the University of California, where he pursued a degree in dentistry. He transferred to Washington College in Irvington, California. While playing baseball for the school's baseball team, he received an offer to play semi-professional baseball for a team in Sullivan, Illinois, for $40 a month ($1,512 in current dollar terms), which he accepted.

Returning to college the next year, Chance led his team to a third-place finish in an amateur tournament of 50 teams. Bill Lange of the Chicago Cubs discovered Chance and convinced the Cubs to sign him as a backup catcher and outfielder, receiving $1,200 a year ($45,355 in current dollar terms). Chance was scouted by other teams, but chose the Cubs as Tim Donohue was the only catcher ahead of him on the Cubs' depth chart.

Chance began his career in 1898 with the Chicago Cubs, serving as a reserve catcher and outfielder. He played irregularly through the 1902 season. Due in part to finger injuries suffered while catching, Chance played in no more than 75 games in a season through 1902. In 1903, Johnny Kling became the Cubs' full-time catcher. As Bill Hanlon, the Cubs' first baseman, left the team, manager Frank Selee moved Chance to first base. Though Chance initially balked at the position change, he agreed when he received a pay raise.