The Gen 75 Committee was a committee of the British cabinet, convened by the Prime Minister, Clement Attlee, on 10 August 1945. It was one of many ad hoc cabinet committees, each of which was convened to handle a single issue, and given a prefix of Gen (for general) and a number. The purpose of the Gen 75 committee was to discuss and establish the British government's nuclear policy. Attlee dubbed it the "Atom Bomb Committee". It was replaced by an official ministerial committee, the Atomic Energy Committee, in February 1947.

Matters considered by the Gen 75 Committee included decisions on what production facilities should be built to produce nuclear weapons, authorising the construction of nuclear reactors to produce plutonium at Windscale, and a gaseous diffusion plant to produce uranium-235 at Capenhurst. It took decisions on the administrative structures that would oversee production, and appointed Marshal of the Royal Air Force Lord Portal, the wartime Chief of the Air Staff, to run the project, which became High Explosive Research. The final decision to proceed with building nuclear weapons, however, was made by another Gen committee, the Gen 163 Committee.

During the early part of the Second World War, Britain had a nuclear weapons project, codenamed Tube Alloys. A directorate of that name coordinated this effort. Sir John Anderson, the Lord President of the Council, was the minister responsible, and Wallace Akers from Imperial Chemical Industries (ICI) was appointed the director. At the Quadrant Conference in August 1943, the Prime Minister, Winston Churchill and the President of the United States, Franklin Roosevelt, signed the Quebec Agreement, which merged Tube Alloys with the American Manhattan Project to create a combined British, American and Canadian project. The British considered the Quebec Agreement to be the best deal they could have struck under the circumstances, and the restrictions were the price they had to pay to obtain the technical information needed for a successful post-war nuclear weapons project. Margaret Gowing noted that the "idea of the independent deterrent was already well entrenched."

Many of Britain's top scientists participated in the British contribution to the Manhattan Project. A British mission led by Akers assisted in the development of gaseous diffusion technology at the SAM Laboratories in New York. Another, led by Mark Oliphant, who acted as deputy director at the Berkeley Radiation Laboratory, assisted with the electromagnetic separation process. John Cockcroft became the director of the Anglo-Canadian Montreal Laboratory. The British mission to the Los Alamos Laboratory led by James Chadwick, and later Rudolf Peierls, included distinguished scientists such as Geoffrey Taylor, James Tuck, Niels Bohr, William Penney, Otto Frisch, Ernest Titterton and Klaus Fuchs, who was later revealed to be a spy for the Soviet Union. As overall head of the British Mission, Chadwick forged a close and successful partnership with Brigadier General Leslie R. Groves, the director of the Manhattan Project, and ensured that British participation was complete and wholehearted.

The Government of the United Kingdom is directed by the cabinet, a group of senior government ministers led by the Prime Minister. Most of the day-to-day work of the cabinet is carried out by cabinet committees, rather than by the full cabinet. Each committee has its own area of responsibility, and their decisions are binding on the entire cabinet. Their membership and scope is determined by the Prime Minister.

During the post-Second World War period, in addition to standing committees, there were ad hoc committees that were convened to handle a single issue. These were normally short-lived. Each was given a prefix of Gen and a number. Gen 183, for example, was the Committee on Subversive Activities. Between 1945 and 1964, Gen (for general) committees were sequentially numbered from 1 to 881 in order of formation.

Prime Minister Clement Attlee, who succeeded Churchill in June 1945, created the Gen 75 Committee on 10 August 1945 to examine the feasibility of a nuclear weapons programme. It was known informally by Attlee as the "Atomic Bomb Committee", although no explicit decision to build one was made until January 1947. The Gen 75 Committee differed from other Gen committees in that its deliberations were not reported to the full cabinet, and were shrouded in secrecy even at that level. The entire subject of nuclear weapons was kept off the full cabinet agenda, and cabinet ministers not attending the meetings may not have even known of its existence.

Membership of Gen 75 initially consisted of five ministers: the Prime Minister, Clement Attlee; the Lord President of the Council, Herbert Morrison; the Foreign Secretary, Ernest Bevin; and the President of the Board of Trade, Stafford Cripps. It was soon expanded with the addition of the Lord Privy Seal, Arthur Greenwood, and the Chancellor of the Exchequer, Hugh Dalton. After the Gen 75 Committee decided that the nuclear weapons project should be the responsibility of the Ministry of Supply, the Minister of Supply, John Wilmot, was added.