A geographic information system (GIS) consists of integrated computer hardware and software that store, manage, analyze, edit, output, and visualize geographic data. Much of this often happens within a spatial database; however, this is not essential to meet the definition of a GIS. In a broader sense, one may consider such a system also to include human users and support staff, procedures and workflows, the body of knowledge of relevant concepts and methods, and institutional organizations.

The uncounted plural, geographic information systems, also abbreviated GIS, is the most common term for the industry and profession concerned with these systems. The academic discipline that studies these systems and their underlying geographic principles, may also be abbreviated as GIS, but the unambiguous GIScience is more common. GIScience is often considered a subdiscipline of geography within the branch of technical geography.

Geographic information systems are used in multiple technologies, processes, techniques and methods. They are attached to various operations and numerous applications, that relate to: engineering, planning, management, transport/logistics, insurance, telecommunications, and business, as well as the natural sciences such as forestry, ecology, and Earth science. For this reason, GIS and location intelligence applications are at the foundation of location-enabled services, which rely on geographic analysis and visualization.

GIS provides the ability to relate previously unrelated information, through the use of location as the "key index variable". Locations and extents that are found in the Earth's spacetime are able to be recorded through the date and time of occurrence, along with x, y, and z coordinates; representing, longitude (x), latitude (y), and elevation (z). All Earth-based, spatial–temporal, location and extent references should be relatable to one another, and ultimately, to a "real" physical location or extent. This key characteristic of GIS has begun to open new avenues of scientific inquiry and studies.

While digital GIS dates to the mid-1960s, when Roger Tomlinson first coined the phrase "geographic information system", many of the geographic concepts and methods that GIS automates date back decades earlier.

One of the first known instances in which spatial analysis was used came from the field of epidemiology in the Rapport sur la marche et les effets du choléra dans Paris et le département de la Seine (1832). French cartographer and geographer Charles Picquet created a map outlining the forty-eight districts in Paris, using halftone color gradients, to provide a visual representation for the number of reported deaths due to cholera per every 1,000 inhabitants.

In 1854, John Snow, an epidemiologist and physician, was able to determine the source of a cholera outbreak in London through the use of spatial analysis. Snow achieved this through plotting the residence of each casualty on a map of the area, as well as the nearby water sources. Once these points were marked, he was able to identify the water source within the cluster that was responsible for the outbreak. This was one of the earliest successful uses of a geographic methodology in pinpointing the source of an outbreak in epidemiology. While the basic elements of topography and theme existed previously in cartography, Snow's map was unique due to his use of cartographic methods, not only to depict, but also to analyze clusters of geographically dependent phenomena.

The early 20th century saw the development of photozincography, which allowed maps to be split into layers, for example one layer for vegetation and another for water. This was particularly used for printing contours – drawing these was a labour-intensive task but having them on a separate layer meant they could be worked on without the other layers to confuse the draughtsman. This work was initially drawn on glass plates, but later plastic film was introduced, with the advantages of being lighter, using less storage space and being less brittle, among others. When all the layers were finished, they were combined into one image using a large process camera. Once color printing came in, the layers idea was also used for creating separate printing plates for each color. While the use of layers much later became one of the typical features of a contemporary GIS, the photographic process just described is not considered a GIS in itself – as the maps were just images with no database to link them to.