Gepefrine, also known as 3-hydroxyamphetamine or α-methyl-meta-tyramine and sold under the brand names Pressionorm and Wintonin, is a sympathomimetic medication used as an antihypotensive agent which has been marketed in Germany.

Gepefrine is described as a sympathomimetic and antihypotensive agent.

Gepefrine, also known as 3-hydroxy-α-methylphenethylamine or as 3-hydroxyamphetamine, is a substituted phenethylamine and amphetamine derivative. It is used pharmaceutically as the (S)-enantiomer and as the tartrate salt. Related compounds include meta-tyramine (3-hydroxyphenethylamine), 4-hydroxyamphetamine (norpholedrine), 3,4-dihydroxyamphetamine (α-methyldopamine), and metaraminol ((1R,2S)-3,β-dihydroxyamphetamine), among others.

Gepefrine was synthesized by 1968 and was introduced for medical use in Germany by 1981.

Gepefrine is the generic name of the drug and its INNTooltip International Nonproprietary Name. Brand names of gepefrine include Pressionorm and Wintonin.

Gepefrine is a known metabolite of amphetamine in rats.