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Gi alpha subunit

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Gi alpha subunit

Gi protein alpha subunit is a family of heterotrimeric G protein alpha subunits. Gi proteins primarily inhibit the cAMP dependent pathway by inhibiting adenylyl cyclase activity, resulting in decreased activity of cAMP-dependent protein kinase (PKA). This family is also commonly called the Gi/o (Gi /Go ) family or Gi/o/z/t family to include closely related family members. G alpha subunits may be referred to as Gi alpha, Gαi, or Giα.

There are four distinct subtypes of alpha subunits in the Gi/o/z/t alpha subunit family that define four families of heterotrimeric G proteins:

Gi1α is encoded by the gene GNAI1.

Gi2α is encoded by the gene GNAI2.

Gi3α is encoded by the gene GNAI3.

Go1α is encoded by the gene GNAO1.

Gzα is encoded by the gene GNAZ.

Transducin/Gt1α is encoded by the gene GNAT1.

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