Gorakhpur is a city in the Indian state of Uttar Pradesh, along the banks of the Rapti river in the Purvanchal region. It is situated 272 kilometres east of the state capital, Lucknow. It is the administrative headquarters of Gorakhpur district, North Eastern Railway Zone and Gorakhpur division. The city is home to the Gorakhnath Math, a Gorakhnath temple. The city also has had an Indian Air Force station since 1963. Gita Press, the world's largest publisher of Hindu religious texts like Ramayana and Mahabharata, has been established here since 1926.

The name "Gorakhpur" comes from the Sanskrit Gorakshapuram, which means abode of Gorakshanatha, a renowned ascetic who was a prominent saint of the Nath Sampradaya.

The earliest forerunners of the settlement at Gorakhpur were probably "considerably to the north of the present town" because the course of the Rapti was then more to the north and east than it is today; it would have flowed through the present-day city and gone through what is now the Ramgarh Tal. Farmers digging wells in the 1800s/early 1900s would sometimes encounter pieces of old boats, which is indicative of the river's shift in course. The site of Gorakhpur would have been desirable for a human settlement because of its secure location — it is protected on the south and west by the Rapti and Rohin rivers, and in the past there were dense forests on the north and east, offering protection on those sides as well.

The earliest event described in local tradition is the legendary construction of the Mansarowar and Kauladah tanks, in the area now called Purana Gorakhpur, in the 10th century. They are said to have been built by a married couple — Mansarowar is attributed to the husband, the prince Man Sen, while Kauladah is attributed to the wife, Kaulavati. Sometime after that, the area is said to have been ruled by a group known as the Domkatars Bhumihars, who built the Domingarh fort at the confluence of the Rapti and Rohin rivers. Still later, Gorakhpur is said to have been ruled by the Shrinet Rajputss of Satasi. Sometime around 1400, a family dispute is said to have prompted one branch of the Satasi dynasty to leave the old stronghold, on the shore of Ramgarh Tal, and move to a new location in what is now Purana Gorakhpur, near the shrine of the renowned ascetic Gorakhnath.

In any case, Gorakhpur had become a large town by the time of Akbar, in the late 1500s. The earliest contemporary reference to a Mughal garrison at Gorakhpur is in 1572, when it was governed by Payanda Khan on behalf of Munim Khan, then subahdar of Jaunpur. Gorakhpur was for a long time the main Muslim garrison north of the Ghaghra, which may explain why it has such a prominent Muslim presence compared to other parts of the district.

In the Ain-i-Akbari (c. 1595), Gorakhpur is listed as the capital of a sarkar in the subah of Awadh. Sarkar Gorakhpur was divided into 24 mahals, and Gorakhpur itself was one of them. The mahal of Gorakhpur was listed with an assessed revenue of 567,385 dams and was expected to supply 200 infantry and 40 cavalry to the Mughal army. It was described as having a brick fort on the Rapti.

Gorakhpur also had a mint under Akbar, issuing copper coins only. By the time of Aurangzeb, the Gorakhpur mint was also issuing silver coins. During the 1600s, based on Jean-Baptiste Tavernier's account of his travels in India, Gorakhpur played an important role as a centre for trade with the northern mountain regions.

In the late 1600s, Gorakhpur was officially renamed Mu'azzamabad in honour of Prince Mu'azzam (the later Bahadur Shah I), and this name was used in official documents until the British takeover in 1801. After Emperor Bahadur Shah's ascension in 1707, Chin Qulich Khan was appointed faujdar of Gorakhpur but resigned in 1710 due to a loss of favour. From this time, local Rajput chiefs, known as rajas, exercised de facto control over the region, assigning lands and titles, with minimal intervention from the Mughal imperial officers.