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Hans Selye
János Hugo Bruno "Hans" Selye CC (/ˈsɛljeɪ/[dubious – discuss]; Hungarian: Selye János Hungarian pronunciation: [ˈʃɛjɛ]; January 26, 1907 – October 16, 1982) was a Hungarian-Canadian endocrinologist who conducted important scientific work on the hypothetical non-specific response of an organism to stressors. Although he did not recognize all of the many aspects of glucocorticoids, Selye was aware of their role in the stress response.
Selye was born in Vienna, Austria-Hungary on January 26, 1907, and grew up in Komárom (the town with Hungarian majority in present-day Slovakia was cut by the Treaty of Trianon in 1920). Selye's father was a doctor of Hungarian ethnicity and his mother was Austrian. He became a Doctor of Medicine and Chemistry in Prague in 1929 and went on to do pioneering work in stress and endocrinology at Johns Hopkins University, McGill University, and the Université de Montréal. He was nominated for the Nobel Prize in Physiology or Medicine for the first time in 1949. Although he received a total of 17 nominations (1949–1953) in his career, he never won the prize.
Selye died on October 16, 1982, in Montreal, Quebec, Canada. He often returned to visit Hungary, giving lectures as well as interviews in Hungarian television programs. He conducted a lecture in 1973 at the Hungarian Scientific Academy in Hungarian and observers noted that he had no accent, despite spending many years abroad. His book The Stress of Life appeared in Hungarian as Az Életünk és a stressz in 1964 and became a bestseller. Selye János University, the only Hungarian-language university in Slovakia, was named after him. Selye's mother was killed by gunfire during Hungary's anti-Communist revolt of 1956.
Selye's interest in stress began when he was in medical school; he had observed that patients with various chronic illnesses like tuberculosis and cancer appeared to display a common set of symptoms that he attributed to what is now commonly called stress. After completing his medical degree and a doctorate degree in organic chemistry at the German University of Prague, he received a Rockefeller Foundation fellowship to study (1931) at Johns Hopkins in Baltimore and later moved to the Department of Biochemistry at McGill University in Montreal in 1932 where he studied under the sponsorship of James Bertram Collip (1892–1965). While working with laboratory animals, Selye observed a phenomenon that he thought resembled what he had previously seen in chronic patients. Rats exposed to cold, drugs, or surgical injury exhibited a common pattern of responses to these stressors. (A stressor is a chemical or biological agent, environmental condition, external stimulus or an event seen as causing stress to an organism.)
Selye initially (c. 1940s) called this the "general adaptation syndrome" (at the time it was also called "Selye's syndrome"), but he later rebaptized it with the simpler term "stress response". According to Selye the general adaptation syndrome is triphasic, involving an initial alarm phase followed by a stage of resistance or adaptation and, finally, a stage of exhaustion and death (these phases were established largely on the basis of glandular states). Working with doctoral student Thomas McKeown (1912–1988), Selye published a report that used the word "stress" to describe these responses to adverse events.[need quotation to verify]
His last inspiration for general adaptation syndrome came from an experiment in which he injected mice with extracts of various organs. He at first believed that he had discovered a new hormone, but was proved wrong when every irritating substance he injected produced the same symptoms (swelling of the adrenal cortex, atrophy of the thymus, gastric and duodenal ulcers). This, paired with his observation that people with different diseases exhibit similar symptoms, led to his description of the effects of "noxious agents" as he at first called it. He later adopted the term "stress", which has been accepted into the lexicon of many languages.
Selye argued that stress differs from other physical responses in that it is identical whether the provoking impulse is positive or negative. He called negative stress "distress" and positive stress "eustress".
The system whereby the body copes with stress, the hypothalamic-pituitary-adrenal axis (HPA axis) system, was also first described by Selye.
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Hans Selye
János Hugo Bruno "Hans" Selye CC (/ˈsɛljeɪ/[dubious – discuss]; Hungarian: Selye János Hungarian pronunciation: [ˈʃɛjɛ]; January 26, 1907 – October 16, 1982) was a Hungarian-Canadian endocrinologist who conducted important scientific work on the hypothetical non-specific response of an organism to stressors. Although he did not recognize all of the many aspects of glucocorticoids, Selye was aware of their role in the stress response.
Selye was born in Vienna, Austria-Hungary on January 26, 1907, and grew up in Komárom (the town with Hungarian majority in present-day Slovakia was cut by the Treaty of Trianon in 1920). Selye's father was a doctor of Hungarian ethnicity and his mother was Austrian. He became a Doctor of Medicine and Chemistry in Prague in 1929 and went on to do pioneering work in stress and endocrinology at Johns Hopkins University, McGill University, and the Université de Montréal. He was nominated for the Nobel Prize in Physiology or Medicine for the first time in 1949. Although he received a total of 17 nominations (1949–1953) in his career, he never won the prize.
Selye died on October 16, 1982, in Montreal, Quebec, Canada. He often returned to visit Hungary, giving lectures as well as interviews in Hungarian television programs. He conducted a lecture in 1973 at the Hungarian Scientific Academy in Hungarian and observers noted that he had no accent, despite spending many years abroad. His book The Stress of Life appeared in Hungarian as Az Életünk és a stressz in 1964 and became a bestseller. Selye János University, the only Hungarian-language university in Slovakia, was named after him. Selye's mother was killed by gunfire during Hungary's anti-Communist revolt of 1956.
Selye's interest in stress began when he was in medical school; he had observed that patients with various chronic illnesses like tuberculosis and cancer appeared to display a common set of symptoms that he attributed to what is now commonly called stress. After completing his medical degree and a doctorate degree in organic chemistry at the German University of Prague, he received a Rockefeller Foundation fellowship to study (1931) at Johns Hopkins in Baltimore and later moved to the Department of Biochemistry at McGill University in Montreal in 1932 where he studied under the sponsorship of James Bertram Collip (1892–1965). While working with laboratory animals, Selye observed a phenomenon that he thought resembled what he had previously seen in chronic patients. Rats exposed to cold, drugs, or surgical injury exhibited a common pattern of responses to these stressors. (A stressor is a chemical or biological agent, environmental condition, external stimulus or an event seen as causing stress to an organism.)
Selye initially (c. 1940s) called this the "general adaptation syndrome" (at the time it was also called "Selye's syndrome"), but he later rebaptized it with the simpler term "stress response". According to Selye the general adaptation syndrome is triphasic, involving an initial alarm phase followed by a stage of resistance or adaptation and, finally, a stage of exhaustion and death (these phases were established largely on the basis of glandular states). Working with doctoral student Thomas McKeown (1912–1988), Selye published a report that used the word "stress" to describe these responses to adverse events.[need quotation to verify]
His last inspiration for general adaptation syndrome came from an experiment in which he injected mice with extracts of various organs. He at first believed that he had discovered a new hormone, but was proved wrong when every irritating substance he injected produced the same symptoms (swelling of the adrenal cortex, atrophy of the thymus, gastric and duodenal ulcers). This, paired with his observation that people with different diseases exhibit similar symptoms, led to his description of the effects of "noxious agents" as he at first called it. He later adopted the term "stress", which has been accepted into the lexicon of many languages.
Selye argued that stress differs from other physical responses in that it is identical whether the provoking impulse is positive or negative. He called negative stress "distress" and positive stress "eustress".
The system whereby the body copes with stress, the hypothalamic-pituitary-adrenal axis (HPA axis) system, was also first described by Selye.
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