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High-risk pregnancy

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High-risk pregnancy

A high-risk pregnancy is a pregnancy where the gestational carrier or the fetus has an increased risk of adverse outcomes compared to uncomplicated pregnancies. No concrete guidelines currently exist for distinguishing "high-risk" pregnancies from "low-risk" pregnancies; however, there are certain studied conditions that have been shown to put the gestational carrier or fetus at a higher risk of poor outcomes. These conditions can be classified into three main categories: health problems in the gestational carrier that occur before the pregnancy, health problems in the gestational carrier that occur during pregnancy, and certain health conditions with the fetus. There are typically ways to medically manage all of these complications, as well as emotionally manage them with anxiety management and high-risk pregnancy specialists.

In 2012, the CDC estimated that there are approximately 65,000 pregnancies deemed "high-risk" in the United States each year. Across the US, 6-8% of women develop a high-risk complication within their pregnancy. Globally, there are 20 million high-risk pregnancies each year.

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Pregnancies may be considered high-risk if the gestational parent has certain pre-existing health conditions. These include age, chronic high blood pressure, pre-existing diabetes, cardiac/heart diseases, and autoimmune disease.

Older age is considered to be a risk factor in pregnancies. Pregnancies in gestational parents over the age of 35 are considered "advanced age". First-time pregnant gestational parents in this age group may have normal pregnancies, but research indicates that these women are at increased risk of having: first trimester miscarriage, chromosomal abnormalities in the fetus, and fetal growth restriction (FGR). Advanced age is associated with a higher risk for fetal chromosomal abnormalities such as Down Syndrome (Trisomy 21) and Trisomy 13. Some of these chromosomal abnormalities are further associated with an increased risk of miscarriage in the first trimester. It is not yet well-understood how older age leads to increased risk of FGR, but studies have suggested that it could be related to placenta dysfunction. Furthermore, younger age can also be a risk factor in pregnancies. Pregnant teenagers are more likely to develop anemia, have preterm births, and have low birth weight babies.

Having chronic high blood pressure can further lead to high-risk pregnancies. The CDC estimates the rate of chronic hypertension in the US as 166.9 per 100,000 hospital deliveries. Hypertension is considered a risk factor for high-risk pregnancy because it leads to an increased risk of pre-eclampsia, restricted fetal growth, and preterm birth. It is not yet well-understood how hypertension leads to increased risk of these outcomes. However, it is thought that hypertension leads to decreased blood flow to the placenta. Decreased blood flow to the fetus could lead to restricted growth and trigger other changes that increase the risk of pre-eclampsia, restricted fetal growth, and pre-term birth.

Pre-existing diabetes that is not managed during pregnancy is associated with increased risk of spontaneous abortions in the first few weeks of pregnancy and increased risk of congenital malformations such as congenital heart defects and neural tube defects. The mechanism through which hyperglycemia results in these malformations is still an area being studied, but increased oxidative stress resulting from hyperglycemia is a potential contributor. Pre-existing diabetes is also associated with an increased risk of high birth weight or macrosomia and preterm birth. Macrosomia can put the fetus at risk of brachial plexus injury due to shoulder dystocia during vaginal delivery.

During pregnancy, there is an increase in the volume of circulating blood. In gestational parents with cardiac disease, this increased blood volume can worsen/exacerbate existing heart disease.Autoimmune disease can also cause high-risk pregnancies, as the varying symptoms can induce chronic stress, fatigue, and other illnesses.

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