Hyōgo Prefecture (兵庫県, Hyōgo-ken; Japanese pronunciation: [çoꜜː.ɡo, -ŋo, çoː.ɡoꜜ.keɴ, -ŋoꜜ.keɴ]) is a prefecture of Japan located in the Kansai region of Honshu. Hyōgo Prefecture has a population of 5,469,762 (as of 1 June 2019^[update]) and a geographic area of 8,400 square kilometres (3,200 square miles). Hyōgo Prefecture borders Kyoto Prefecture to the east, Osaka Prefecture to the southeast, and Okayama and Tottori prefectures to the west.

Kobe is the capital and largest city of Hyōgo Prefecture, and the seventh-largest city in Japan, with other major cities including Himeji, Nishinomiya, and Amagasaki. Hyōgo Prefecture's mainland stretches from the Sea of Japan to the Seto Inland Sea, where Awaji Island and a small archipelago of islands belonging to the prefecture are located. Hyōgo Prefecture is a major economic center, transportation hub, and tourist destination in western Japan, with 20% of the prefecture's land area designated as Natural Parks. Hyōgo Prefecture forms part of the Kobe metropolitan area and Osaka metropolitan area, the second-most-populated urban region in Japan after the Greater Tokyo area and one of the world's most productive regions by GDP.

Present-day Hyōgo Prefecture includes the former provinces of Harima, Tajima, Awaji, and parts of Tanba and Settsu.

In 1180, near the end of the Heian period, Emperor Antoku, Taira no Kiyomori, and the Imperial court moved briefly to Fukuhara, in what is now the city of Kobe. There the capital remained for five months. Himeji Castle, a UNESCO World Heritage Site, is in the city of Himeji.

Southern Hyōgo Prefecture was severely devastated by the 6.9 Mw Great Hanshin earthquake of 1995, which destroyed major parts of Kobe and Awaji, as well as Nishinomiya and Ashiya and the neighboring Osaka Prefecture, killing nearly 6,500 people.

Hyōgo has coastlines on two seas: to the north, the Sea of Japan, to the south, the Seto Inland Sea. On Awaji Island, Hyōgo borders the Pacific Ocean coastline in the Kii Channel. The northern portion is sparsely populated, except for the city of Toyooka, The central highlands are only populated by tiny villages. Most of Hyōgo's population lives on the southern coast, which is part of the Osaka-Kobe-Kyoto metropolitan area. Awaji is an island that separates the Inland Sea and Osaka Bay, lying between Honshu and Shikoku.

Summertime weather throughout Hyōgo is hot and humid. As for winter conditions, the north of Hyōgo tends to receive abundant snow, whilst the south receives only the occasional flurry.

Hyōgo borders on Osaka Prefecture, Kyoto Prefecture, Tottori Prefecture and Okayama Prefecture.