Synesius of Cyrene studied with Hypatia in Alexandria. He considered her a highly respected teacher and philosopher, and he maintained a close intellectual relationship with her.

Synesius and Hypatia exchanged letters on a variety of topics, including philosophy, politics, and personal matters. These letters provide insight into Hypatia's philosophical views and her influence on Synesius's thinking. The surviving letters are a vital source of information about Hypatia.

Synesius later became the Bishop of Ptolemais. Despite his conversion to Christianity and his role as a bishop, he continued to seek Hypatia's advice on philosophical matters, demonstrating her enduring influence on his intellectual life.

Synesius died a few years after Hypatia's murder. His passing represented a significant loss of a critical voice that valued Hypatia's intellect and memory within the shifting Alexandrian landscape.