Interstate 94 (I-94) in the US state of Minnesota runs 259 miles (417 km) east–west through the central portion of the state. The highway connects the cities of Moorhead, Fergus Falls, Alexandria, St. Cloud, Minneapolis, and Saint Paul. Authorized in 1956, it was mostly constructed in the 1960s. For its whole length, it runs concurrently with either US Highway 52 (US 52) or US 12.

I-94 enters the state from North Dakota at the city of Moorhead and heads southeast after serving Moorhead.

Traveling southeast from Moorhead, there are several places where the elevation of I-94 rises slightly; these are "beaches" that formed as the glacial lake rose or fell. Finally, at Rothsay, I-94 climbs the last beach line and enters terrain more typical for Minnesota. From Rothsay to the Twin Cities, the terrain of I-94 is rolling with frequent lakes visible from the highway.

I-94 traverses by Fergus Falls, Alexandria, and Sauk Centre on its way to St. Cloud. The "original main street" in Sauk Centre near I-94 commemorates the Sinclair Lewis novel that skewered this town.

Monticello is roughly the midpoint exurb for both St. Cloud and Minneapolis. Between exits 201 (Albertville) and 194 (Monticello) sits the Minnesota Road Research Facility.

Upon arrival to the Twin Cities, I-94 first approaches Minneapolis from the north, then the highway turns east after passing through the Lowry Hill Tunnel and heads to Saint Paul while traveling east.

The road crosses the Mississippi River in Minneapolis between the Prospect Park and Seward neighborhoods. The highway joins Minneapolis and Saint Paul together where it meets Minnesota State Highway 280 (MN 280). In Saint Paul, the routing of I-94 is set through the historic Rondo neighborhood, which, prior to the highway's construction, was the largest Black community in Saint Paul.

Upon leaving Saint Paul, the route travels through suburban Washington County and exits the state into Wisconsin between Lakeland, Minnesota, and Hudson, Wisconsin, while crossing the St. Croix River.