Isaiah 52 is the fifty-second chapter of the Book of Isaiah in the Hebrew Bible or the Old Testament of the Christian Bible. This book contains the prophecies attributed to the prophet Isaiah, and is one of the Books of the Prophets. Chapters 40-55 are known as "Deutero-Isaiah" and date from the time of the Israelites' exile in Babylon. This chapter includes from verse 13 the start of the fourth of the songs of the "Suffering Servant".

The original text was written in Hebrew language. This chapter is divided into 15 verses.

Some early manuscripts containing the text of this chapter in Hebrew are found among the Dead Sea Scrolls, i.e., the Isaiah Scroll (1Qlsa^a; 356-100 BCE), and of the Masoretic Text tradition, which includes Codex Cairensis (895 CE), the Petersburg Codex of the Prophets (916), Aleppo Codex (10th century), Codex Leningradensis (1008).

There is also a translation into Koine Greek known as the Septuagint, made in the last few centuries BCE. Extant ancient manuscripts of the Septuagint version include Codex Vaticanus (B; ${\displaystyle {\mathfrak {G}}}$^B; 4th century), Codex Sinaiticus (S; BHK: ${\displaystyle {\mathfrak {G}}}$^S; 4th century), Codex Alexandrinus (A; ${\displaystyle {\mathfrak {G}}}$^A; 5th century) and Codex Marchalianus (Q; ${\displaystyle {\mathfrak {G}}}$^Q; 6th century).

The parashah sections listed here are based on the Aleppo Codex. Isaiah 52 is a part of the Consolations (Isaiah 40–66). {P}: open parashah; {S}: closed parashah.

The New King James Version organises this chapter as follows:

The call, Awake, awake (Hebrew: עורי עורי ‘ūrî ‘ūrî) repeats the same call heard in Isaiah 51:9 and Isaiah 51:17.

The second line is rendered in the Greek Septuagint version as: "For those who were not told will see, and those who have not heard will understand", which is cited in Romans 15:21.