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Janice Chen
Janice Chen
Janice Chen
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Janice Chen is the co-founder and chief technology officer of Mammoth Biosciences, a Brisbane, California-based company, founded in 2018, that is developing diagnostic tests using CRISPR.[1][2][3] She received her B.S. degree from Johns Hopkins University and her Ph.D. in Molecular and Cell Biology.[3] from the University of California, Berkeley, where she worked in the lab of CRISPR pioneer Jennifer Doudna.

Key Information

Awards and honors

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Along with two of her co-founders at Mammoth Biosciences, Chen was named to the 2019 Forbes 30 Under 30 Healthcare list[4] and 2020 Business Insider's 30 Under 40 in Healthcare.[5] She was also selected to the 2020 Endpoints Top 20 Women in Biopharma,[6] and 35 Innovators Under 35 in MIT Technology Review in 2021.[7]

Personal life

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Chen grew up in Salt Lake City, Utah, and is one of five siblings.[8] Her youngest brother is Olympic figure skater Nathan Chen.[9] Their parents had immigrated to the United States from China in 1988. Chen competed in chess tournaments, where she was often the youngest and the only female. She discovered her love of science at her father's biotech business in Utah.

In 2017, Chen and fellow Berkeley classmate and researcher Lucas Harrington, along with their doctoral advisor, Nobel laureate and Berkeley professor Jennifer Doudna, founded Mammoth Biosciences, a biotech company in San Francisco's Dogpatch neighborhood. In September 2021, Mammoth—now in a state-of-the-art facility in Brisbane, California—completed its seventh round of funding, raising US$195 million at a valuation of over US$1 billion.[8]

References

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Janice Chen

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Janice Chen is an American biochemist and entrepreneur who co-founded Biosciences in 2017 and serves as its , leading the development of CRISPR-based technologies for diagnostics and therapeutics. During her Ph.D. research in the laboratory of Nobel laureate at the , Chen investigated CRISPR-Cas protein mechanisms and co-invented the DETECTR platform, a CRISPR-Cas12a-based system for rapid, programmable DNA detection that enables point-of-care diagnostics for diseases such as human papillomavirus and SARS-CoV-2. She earned a B.S. in Molecular and Cell Biology from in 2013 and a Ph.D. in Molecular and Cell Biology from UC Berkeley in 2018, where her dissertation focused on harnessing for diagnostic applications. At Mammoth Biosciences, headquartered in , Chen oversees the translation of these innovations into commercial products, including CRISPR-based gene editing technologies and the DETECTR assay, which was adapted for during the . Her contributions to diagnostics have earned her recognition as a 2019 honoree in Healthcare, as well as features in MIT Technology Review's 35 Innovators Under 35 and Business Insider's 30 Under 40 in Healthcare. Chen has also delivered public talks on democratizing diagnostics through , including a 2018 TEDxCERN presentation, and holds multiple patents related to technologies.

Early life and education

Early life and family

Janice Chen was born and raised in , one of five siblings in a family of Chinese immigrants. Her parents, Zhidong Chen and Hetty Wang, emigrated from to the in 1988, with Zhidong hailing from the region. The family includes her sister Alice, brothers Tony and Colin, and brother , an Olympic gold medalist in whose 2022 success highlighted the siblings' mutual support. Growing up in an immigrant household presented challenges, including cultural adjustment and economic pressures, yet her parents placed a strong emphasis on education and personal achievement to foster resilience and opportunity for their children. Chen excelled in extracurricular pursuits during her childhood, mastering the violin, competing in chess tournaments—often as the youngest and only female participant—and performing in dance. These activities reflected the family's encouragement of diverse talents amid their pursuit of excellence. Her early exposure to bioscience came through her father's ownership of a small biotech supply company in , where she assisted and developed an initial fascination with scientific innovation. This environment, combined with the immigrant ethos of perseverance, shaped her formative years and instilled a drive for intellectual and creative exploration.

Education

Chen received a B.S. in Molecular and Cellular Biology from . Chen then pursued graduate studies at the , where she earned a Ph.D. in Molecular and Cell Biology in 2018 under the supervision of in the Doudna Lab. During her doctoral training, her research centered on the mechanisms of CRISPR-Cas systems, building on her undergraduate foundation and bridging to advanced gene editing applications.

Scientific and professional career

Graduate research

Janice Chen conducted her PhD research in the laboratory of Jennifer Doudna at the University of California, Berkeley, from approximately 2014 to 2018, focusing on the mechanisms and applications of CRISPR-Cas systems for gene editing and molecular diagnostics. Her work centered on exploring the biochemical properties of diverse Cas enzymes to expand their utility beyond traditional genome editing, particularly in developing sensitive detection methods for nucleic acids. Under Doudna's mentorship, which guided the direction toward innovative CRISPR applications, Chen contributed to early efforts in characterizing these systems for rapid, point-of-care diagnostics. A pivotal discovery from Chen's graduate research was the identification of the collateral cleavage activity in Cas12a (previously known as Cpf1), an RNA-guided DNA endonuclease. In a 2018 study published in Science, Chen and colleagues demonstrated that upon binding and cleaving a target double-stranded DNA sequence, activated Cas12a indiscriminately degrades nearby single-stranded DNA, a property termed "collateral activity." This mechanism enables amplification-free detection of specific targets, forming the basis for CRISPR-based diagnostic platforms capable of identifying pathogens or genetic in clinical samples such as , , or . The finding laid the groundwork for the DETECTR (DNA endonuclease-targeted CRISPR trans reporter) system, a precursor technology for portable, low-cost molecular testing. During her PhD, Chen co-authored several peer-reviewed publications on -Cas innovations, including investigations into specificity and engineering for enhanced targeting accuracy, such as a 2017 Nature paper on improved variants with reduced off-target effects. She also contributed to multiple patents assigned to the , covering mechanisms and nucleic acid detection methods, which have influenced subsequent biotechnological developments. These outputs underscored her role in advancing from a genome-editing tool to a versatile platform for diagnostics, emphasizing conceptual advancements in function over exhaustive experimental metrics.

Mammoth Biosciences

In 2017, Janice Chen co-founded Mammoth Biosciences in , initially operating from a San Francisco incubator, alongside , Lucas Harrington, and Nobel laureate , with an initial emphasis on developing -based diagnostic technologies. As (CTO), Chen has led the company's research and development efforts, overseeing the creation of platforms such as DETECTR, which enables rapid disease detection; a notable application was the DETECTR BOOST SARS-CoV-2 Reagent Kit, the first -based test to receive U.S. () for detection in January 2022. Under Chen's leadership, Mammoth Biosciences achieved significant milestones, including raising a total of $265 million in funding by 2022, highlighted by a $195 million round in that propelled the company's valuation to $1 billion with investments from entities like Amazon and individual backer . The company also secured key partnerships, such as multi-year collaborations with in 2022 and in , yielding approximately $100 million in contracts and grants since 2020 to advance applications in therapeutics. Mammoth Biosciences expanded into therapeutics by leveraging ultracompact systems for gene editing, presenting preclinical data in 2025 on candidates like MB-111—a single-dose for persistent chylomicronemia—at the European Society of Gene & Cell Therapy (ESGCT) 32nd Annual Congress, and on editing in non-human at the American Society of Gene & Cell Therapy (ASGCT) 2025 Annual Meeting. In September 2025, the company entered a non-exclusive licensing partnership with VedaBio to enhance diagnostics, further supporting its technological portfolio. Staff numbers grew from 30 to over 130 by 2022, with continued scaling to support ongoing R&D expansion. Chen envisions Mammoth Biosciences evolving into a $100 billion independent entity, pioneering next-generation solutions for both diagnostics and to realize the full potential of genetic .

Awards and honors

Early recognitions

During her PhD at the , Janice Chen received the (NSF) Graduate Research Fellowship in 2014, which recognized her excellence in research focused on mechanisms. In 2019, Chen was named to the list in the Healthcare category, honoring her contributions to -based diagnostics developed during her graduate studies in Jennifer Doudna's lab. Early in her career, Chen gained media attention as a young innovator in gene editing, including a 2018 TEDxCERN talk titled "Could Democratize Diagnostics?" where she discussed the potential of for accessible disease detection.

Major awards

In 2020, Janice Chen received prominent recognition for her leadership in , particularly her role at Biosciences in developing CRISPR-based diagnostics amid the . She was named to Business Insider's 30 Under 40 list in Healthcare, celebrating her contributions to rapid gene-editing tools for disease detection. That same year, Chen was selected for Endpoints News' Top 20 Women in Biopharma, honoring her impact on innovative therapies and diagnostics in the industry. The following year, in 2021, Chen was awarded MIT Technology Review's 35 Innovators Under 35, spotlighting her advancements in technologies for accessible and precise diagnostic platforms. This accolade underscored her transition from academic research to in democratizing gene-editing applications. Chen has earned additional honors reflecting her influence in biotech entrepreneurship, including inclusion in Entrepreneur Magazine's 100 Women of Influence in 2022, which highlighted her pioneering work with Nobel laureate on diagnostics and Mammoth's growth during the pandemic. She also serves as Chair of the Committee at the American Society of Gene & (ASGCT), where she guides strategic discussions on emerging editing technologies and their therapeutic potential. In 2022, profiled Chen as a leading female founder in innovation, tying her recognition to Mammoth Biosciences' achievement of status after raising $195 million in funding, which propelled the company's expansion in gene-editing therapeutics.

Personal life

Family

Janice Chen shares a close-knit relationship with her parents, Zhidong Chen, a research scientist, and Hetty Chen, a medical translator, both of whom immigrated from and instilled a strong emphasis on perseverance and education in their children. As one of five siblings, Chen maintains supportive bonds with her sisters Alice and brothers Tony, Colin, and Nathan, the youngest, whose gold medal win in figure skating at the 2022 Winter Olympics served as a profound family highlight. The family sustains strong extended ties between their roots in Utah, where the Chens raised their children, and California, where Janice Chen resides and pursues her professional endeavors. There are no public details available regarding Chen's spouse or children.

Community involvement

Chen serves on the advisory board of the Life Sciences Entrepreneurship Center at UC Berkeley, where she has mentored early-stage biotech startups since October 2021. In this role, she provides guidance on innovation and commercialization in the life sciences sector, drawing on her expertise to support emerging entrepreneurs. Beyond her primary professional responsibilities, Chen chairs the Committee of the American Society of Gene & Cell Therapy (ASGCT), contributing to leadership and strategic direction for advancing gene editing technologies. This volunteer commitment underscores her dedication to fostering collaboration and progress in the field. Chen is actively involved in diversity, equity, and inclusion efforts within STEM, particularly highlighting the experiences of Asian and immigrant professionals in biotech. She has spoken on these topics at events such as CES 2021, emphasizing the need for role models, support, and acceptance to maximize potential in diverse backgrounds. Residing in the San Francisco Bay Area, she continues to engage with organizations promoting broader societal contributions in biotechnology.

References

  1. https://mammoth.bio/about/
  2. https://www.medicaldesignbriefs.com/component/content/article/38779-leading-women-in-engineering-science-janice-chen-co-founder-cto-mammoth-biosciences
  3. https://www.crunchbase.com/organization/mammoth-biosciences
  4. https://www.science.org/doi/10.1126/science.aar6245
  5. https://www.nature.com/articles/s41587-020-0513-4
  6. https://www.vibconferences.be/speaker/janice-chen
  7. https://www.fiercebiotech.com/medtech/riding-tiger-lab-c-suite-mammoths-janice-chen
  8. https://www.forbes.com/pictures/5bda143431358e5b43352bd7/2019-30-under-30-healthca/
  9. https://worldmedicalinnovation.org/speaker/janice-chen-phd/
  10. https://www.biocom.org/people/janice-chen-phd/
  11. https://www.aiche.org/sbe/community/bio/janice-chen
  12. https://www.youtube.com/watch?v=_r-FIlX1NJY
  13. https://www.cnbc.com/2022/03/12/30-year-old-female-founders-billion-dollar-bet-on-crispr-gene-editing.html
  14. https://www.sltrib.com/sports/2022/02/09/four-years-after/
  15. https://heavy.com/sports/2018/02/nathan-chen-family-parents-olympics-college/
  16. https://www.technologyreview.com/innovator/janice-chen/
  17. https://lsec.berkeley.edu/advisory-board
  18. https://doudnalab.org/people/
  19. https://news.berkeley.edu/2018/02/15/crispr-scissors-cas12a-enables-cutting-edge-diagnostics/
  20. https://www.reuters.com/business/healthcare-pharmaceuticals/nobel-laureate-doudnas-biotech-mammoth-hits-over-1-bln-valuation-2021-09-09/
  21. https://www.businesswire.com/news/home/20220124005618/en/Mammoth-Biosciences-Receives-FDA-Emergency-Use-Authorization-for-First-CRISPR-based-High-Throughput-COVID-19-Test
  22. https://www.nsmedicaldevices.com/company-news/mammoth-biosciences-crispr-covid-19/
  23. https://www.bayer.com/media/en-us/bayer-and-mammoth-biosciences-to-collaborate-on-novel-gene-editing-technology/
  24. https://investors.vrtx.com/news-releases/news-release-details/vertex-and-mammoth-biosciences-announce-collaboration-develop
  25. https://www.businesswire.com/news/home/20251001491001/en/Mammoth-Biosciences-to-Present-Preclinical-Data-on-MB-111-at-the-European-Society-of-Gene-Cell-Therapy-32nd-Annual-Congress
  26. https://www.biospace.com/press-releases/mammoth-biosciences-to-present-preclinical-data-on-in-vivo-gene-editing-of-skeletal-muscle-in-non-human-primates-with-an-ultracompact-crispr-system-at-asgct-2025
  27. https://www.vedabio.com/post/vedabio-expands-crispr-based-molecular-detection-platform-with-mammoth-biosciences-technology
  28. https://www.linkedin.com/in/janiceschen
  29. https://www.forbes.com/video/6115686517001/30-under-30-spotlight-unsung-heroes-in-healthcare-janice-chen--forbes-healthcare-summit-2019/
  30. https://www.ted.com/talks/janice_chen_could_crispr_democratise_diagnostics
  31. https://www.businessinsider.com/30-leaders-under-40-changing-healthcare-2020-9
  32. https://nextshark.com/janice-chen-is-building-crispr-company
  33. https://www.entrepreneur.com/leadership/100-women-of-influence-in-2022/435872
  34. https://members.asgct.org/ASGCTMember/ASGCTMember/Volunteer/Committee-Details.aspx?Code=GENE-EDIT&GroupID=COMMITTEE%252FGENE-EDIT
  35. https://stylecaster.com/entertainment/celebrity-news/1251187/nathan-chen-parents/
  36. https://www.romper.com/entertainment/nathan-chen-parents-siblings
  37. https://www.distractify.com/p/nathan-chen-siblings
  38. https://www.asgct.org/news-publications/asgct-news/asgct-members-lead-congressional-briefing-on-gene-editing
  39. https://www.ces.tech/articles/on-being-asian-and-asian-american-in-tech/
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