Jayyus (Arabic: جيوس) is a Palestinian village near the west border of the West Bank, close to Qalqilya. It is a farming community. According to the Palestinian Central Bureau of Statistics, the village had a population of 3,478 inhabitants in 2017.

Jayyus (including Khirbet Sir) is located 7 kilometers (4.3 mi)-9 kilometers (5.6 mi) northeast of Qalqiliya. It is bordered by Baqat al Hatab and Kafr Laqif to the east, Kafr Jamal, Kafr Zibad and Kafr ‘Abbush to the south, ‘Azzun, ‘Izbat at Tabib, An Nabi Elyas and ‘Arab Abu Farda to the west, and the Green Line to the north.

At Khirbet Sir, just east of Jayyus, two rock-cut tombs have been found, with a large mound with terraces cut in the sides, and a good well below. Byzantine ceramics have also been found.

Jayyus was incorporated into the Ottoman Empire in 1517 with all of Palestine, and in 1596 it appeared in the tax registers as being in the Nahiya of Bani Sa'b of the Liwa of Nablus. It had a population of 24 households and 6 bachelors, all Muslim. The villagers paid taxes on wheat, barley, summer crops, olive trees, occasional revenues, goats and/or beehives; a total of 11,746 akçe. Half of the revenue went to a Muslim charitable endowment.

According to historian Roy Marom, in the 18th or early 19th centuries, residents of Jayyous affiliated with the Qaysi camp during the Qays and Yaman conflicts, alongside residents of Deir Abu Mash'al and part of the residents of Bayt Nabala. They fought several skirmishes against Yamani rivals from Qibya and Dayr Tarif.

In 1838, Robinson noted the village, called Jiyus, as being in the Beni Sa'ab district, west of Nablus.

In the 1860s, the Ottoman authorities granted the village an agricultural plot of land called Ghabat Jayyus in the former confines of the Forest of Arsur (Ar. Al-Ghaba) in the coastal plain, west of the village.

In 1870/1871 (1288 AH), an Ottoman census listed the village in the nahiya (sub-district) of Bani Sa'b.