Jorge Abner Drexler Prada (born 21 September 1964) is a Uruguayan musician and actor. Drexler is known for winning the 2005 Academy Award for Best Original Song for "Al Otro Lado del Río" from The Motorcycle Diaries, becoming the first Uruguayan to win an Oscar and marking the first time a Spanish-language song received the award.

Jorge Abner Drexler Prada was born on 21 September 1940 in Montevideo, the eldest child of Gunther Drexler Schlein (1935–2024) and Lucero Prada da Silveira (1939–2018). His father was a German Jew from Berlin who, at the age of four, fled Nazi persecution in Germany together with his parents, Georg and Ruth Drexler. The family sought refuge in Bolivia before later settling in Uruguay. His mother was a Roman Catholic of mixed Spanish, French, and Portuguese ancestry.

Drexler was raised Jewish and attended both public schools and Jewish educational institutions, including the Instituto Ariel Hebreo Uruguayo. He began playing piano at age five, before attending guitar and composition classes. Although he had an interest in music, he studied medicine, like both of his parents, graduating from the University of the Republic, and specializing in otorhinolaryngology. He also worked as a lifeguard and as a home-visit physician. During his time in medical school, he took a break to hitchhike through Brazil.

In 1995 he was invited to Madrid by well-known Spanish songwriter Joaquín Sabina, who introduced him to other important Spanish singers. Drexler went to Spain to record the album Vaivén in 1996 with Spanish musicians. Vaivén included some old songs from his previous releases mixed with new compositions. He moved to Spain and recorded another four albums: Llueve (1997), Frontera (1999), Sea (2001) and Eco (2004). In 2001, Drexler co-wrote two songs for Spanish singer Rosario Flores ("Agua y Sal" and "Rosa y Miel") for her album Muchas Flores.

Drexler's song "Al Otro Lado del Río" appeared in the internationally acclaimed film The Motorcycle Diaries. Though Drexler himself sang the song on the movie soundtrack, he was not allowed to perform the song at the 2005 Academy Awards, since "he was not popular enough," according to Spanish newspaper El País; Spanish actor Antonio Banderas and Mexican-American musician Carlos Santana sang the track instead. Upon winning, Drexler recited two verses of the song at the podium. Drexler became the first Uruguayan to win an Academy Award.

After that, he released 12 Segundos de Oscuridad (2006); this album contained ten original songs and two covers: "High and Dry" from British band Radiohead and "Disneylandia" from Brazilian Titãs. Although he lives most of the year in Spain, his albums were partially recorded in Uruguay with Uruguayan musicians. Juan Campodónico and Carlos Casacuberta, former members of rock band El Peyote Asesino, had produced Drexler's albums from Frontera to 12 Segundos De Oscuridad. In 2008, he released a double live album, recorded in different concerts in Spain: Cara B (2008), mainly filled with songs previously unreleased. During 2009, Drexler worked with Colombian performer Shakira on the Spanish-language versions of her singles "She Wolf", "Did it Again" and "Waka Waka (This Time for Africa).

Drexler recorded Amar la Trama (2010) on November 1–4, 2009 in Madrid, Spain in just four days, with musicians playing live on studio. Drexler described the album as playful, without "the melancholy and anguish" of 12 Segundos. Amar la Trama was recorded in a television studio in front of a small audience who were selected in an online contest. He chose this format to avoid the "coldness" of the recording studio.

His album Bailar en la Cueva, released in 2014, marked a stylistic shift toward more rhythm-focused and dance-oriented music. Drexler has described the album as contrasting with his earlier works, which he characterized as more introspective and nostalgic. He has also stated that it differs significantly from his previous album, referring to it as the “opposite pole” of Amar la Trama.