Karl Denson (born December 27, 1956) is an American funk and jazz saxophonist, flutist and vocalist from Santa Ana, California. He plays with The Rolling Stones, and leads his own group, Karl Denson's Tiny Universe (KDTU). He co-founded The Greyboy Allstars (GBA), and continues to tour with both KDTU and GBA as well as The Rolling Stones. Formerly, Denson was a member of Lenny Kravitz's band and he has recorded with artists including Jack DeJohnette, Dave Holland, Slightly Stoopid, Blind Boys of Alabama, Blackalicious, Stanton Moore, and Jon Foreman of the band Switchfoot. Denson appears in the 1988 movie Coming To America and in the 2021 sequel Coming 2 America as the saxophonist in the fictional band Sexual Chocolate.

Current members of KDTU include Denson (saxophone, flute, vocals, percussion), Ricio Fruge (trumpet, percussion), Ricky Giordano (guitar), Rashon Murph (keyboards), Parker McAllister (bass), Alfred Jordan (drums), and Danielle Barker (vocals).