Kellee Santiago was born in Caracas, Venezuela. This early exposure to a different culture likely influenced her later work, which often emphasizes emotional experiences and cross-cultural understanding.

Santiago immigrated to the United States with her family during her early childhood. Adjusting to a new culture and language likely fostered adaptability and broadened her perspective, traits that proved invaluable in her career.

Santiago attended USC, where she studied in the Interactive Media Division. This was a crucial period where she gained formal training in game design, development, and the broader interactive entertainment landscape. Her time at USC provided her with the skills and network necessary to enter the industry.