After the release of "Journey", Santiago transitioned from her role at Thatgamecompany. This marked a new chapter in her career, allowing her to explore different opportunities and contribute to the industry in new ways.

Served as an investment partner at Ico Partners, a consulting firm specializing in the video game sector. This position reflects her strategic understanding of the industry and her ability to identify promising new talent and projects.

Joined Sony as Head of Developer Relations. In this role, she focused on fostering strong relationships with independent game developers and supporting the creation of innovative content for PlayStation platforms. This position allowed her to influence the direction of the PlayStation ecosystem and champion indie games.

Currently serves as VP of Business Development at Annapurna Interactive, a renowned indie game publisher known for its curated selection of high-quality and artistically driven titles. Annapurna Interactive have received numerous accolades for the artful presentation of their games. This role continues her focus on supporting and promoting independent game development and bringing unique experiences to players.