Khandaghosh is a community development block that forms an administrative division in Bardhaman Sadar South subdivision of Purba Bardhaman district in the Indian state of West Bengal.

In Peterson's District Gazetteer of 1910 there is mention of Khandaghosh and other police stations in Bardhaman subdivision.

Khandaghosh is located at 23°12′47″N 87°41′23″E / 23.2131°N 87.6898°E / 23.2131; 87.6898.

Khandaghosh CD Block is part of the Khandaghosh Plain, which lies in the south-western part of the district, The Damodar flows through the area. The bed of the Damodar is higher than the surrounding areas and the right bank is protected against floods with embankments in portions of the south of the Damodar River. The region has alluvial soil of recent origin. Unlike the rest of Bardhaman district, which lies to the north of the Damodar River, the Khandaghosh-Jamalpur-Raina area lies on the alluvial plains between the Damodar on its northern/ eastern side and the Dwarakeswar River. As a result, it has been a flood prone area.

Khandaghosh CD Block is bounded by Galsi II and Burdwan I CD Blocks on the north, Raina I and Raina II CD Blocks on the east, Goghat II CD Block, in Hooghly district, in a small section of the south, and Indas CD Block, in Bankura district, on the south and west.

Khandaghosh CD Block has an area of 265.23 km². It has 1 panchayat samity, 10 gram panchayats, 143 gram sansads (village councils), 111 mouzas and 107 inhabited villages. Khandaghosh police station serves this block. Headquarters of this CD Block is at Sagrai.

Gram panchayats of Khandaghosh block/panchayat samiti are: Berugram, Gopalbera, Kaiyor, Khandaghosh, Lodna, Sagrai, Sankari I, Sankari II, Sasanga and Ukhrid.

As per the 2011 Census of India Khandaghosh CD Block had a total population of 189,336, all of which were rural. There were 97,092 (51%) males and 92,244 (49%) females. Population below 6 years was 21,168. Scheduled Castes numbered 73,478 (38.81%) and Scheduled Tribes numbered 4,345 (2.29%).