Kirby Reed is a fictional character in the Scream film series, created by Kevin Williamson and portrayed by Hayden Panettiere. She first appeared in Scream 4 (2011) and returns in Scream VI (2023). The character is a target in the fourth killing spree committed by Ghostface, a mysterious, masked killer who wears a ghost mask and black cloak, to pursue her and her friends. In each film, the killer targets their victims with threatening phone calls and intimate knowledge of their target's lives before one or several of the alleged victims is revealed as a killer.

In Scream 4, Reed is introduced as the best friend of franchise protagonist Sidney Prescott's young cousin, Jill Roberts, a millennial target for a copycat anniversary serial killer wearing the infamous Ghostface costume. Since the original killings, no killer has targeted Woodsboro until 2011, making it the second Woodsboro massacre. Panettiere's character worries for her survival after not receiving a phone call like her best friends. The character is a horror genre savvy, trivia fanatic with a dry sense of humor and sarcastic quip. She shows subtle interest in fellow film geek Charlie Walker. Kirby reappears in Scream VI, now an FBI special agent based in Atlanta who travels to New York to assist in the investigation into the latest Ghostface knockoff mystery.

She is initially slotted into the "sidekick" archetype but outgrows this by the final act. She rises to heroine status by the end and is left near-fatally wounded. Being the only unconfirmed victim of the Woodsboro Remake, Kirby was confirmed alive through a photographic cameo in the fifth entry, making her the sole teen survivor of the fourth film and a final girl.

Kirby has been described as a "fan-favorite" and the fourth film's breakout character.

Kirby's first appearance is in Scream 4 (2011) as the 18-year-old high school senior from the fictional town of Woodsboro, in Northern California. The anniversary week of Billy Loomis (Skeet Ulrich) and Stu Macher (Matthew Lillard)'s original killing spree coincides with the murder of her classmates, Jenny Randall (Aimee Teegarden) and Marnie Cooper (Britt Robertson). She stays at her best friend, Jill Roberts (Emma Roberts)'s house, with her mother, Kate (Mary McDonnell) and Jill's celebrity cousin and heroine, Sidney Prescott (Neve Campbell), whom Kirby admires and looks up to. Kirby credits Sidney for her love of horror movies. They receive police protection from Dewey Riley (David Arquette) by Deputies Perkins (Anthony Anderson) and Hoss (Adam Brody). Kirby gets her first call, amid watching Shaun of the Dead with Jill. Ghostface claims to be in Jill's closet, but it turns out to be their other best friend, Olivia Morris (Marielle Jaffe)'s closet next door, whom they watch get savagely murdered. Kirby tends to Jill after she is slashed on the arm by Ghostface following Olivia's murder.

She attends film geeks Charlie Walker (Rory Culkin) and Robbie Mercer (Erik Knudsen)'s third annual Stab-A-Thon, a Friday night movie marathon celebrating all seven Stab films back-to-back. The venue takes place at an abandoned farm, where Gale Riley (Courteney Cox) is stabbed during the Casey Becker (Heather Graham) opening scene. The sheriff's wife being left in critical condition causes the teens to disperse. The exception to this is Jill, who was prohibited from attending the party by her mother. Kirby is contacted by a snuck-out Jill to pick her up due to her mother "driving [her] crazy", and they invite Robbie and Charlie to Kirby's for an afterparty. Trevor Sheldon (Nico Tortorella)—whom she had been suspicious of—shows up uninvited, much to her annoyance, and Charlie apologizes, being the last arrival. A drunken Kirby almost kisses Charlie, but Trevor barges in again, causing Charlie to storm off.

After Sidney arrives to warn Jill to leave, Ghostface has followed and launches at the three women at the front door after Robbie collapses to his death in front of them; the cousins run upstairs, while Kirby runs to another room in her main hallway. Kirby later reconvenes with Sidney again to say someone has smashed the router and the landline is dead; Sidney informs her she may have gotten in contact with the police. The two find Charlie outside her basement patio doors, where Sidney tells her not to let him in if she cannot trust him. Kirby cries, telling him she cannot open the door.

Ghostface arrives to attack him. Then the lights shut. When they re-open, Charlie is duct-taped and rope-tied to a chair, like Steven Orth (Kevin Patrick Walls) in the original film's opening scene. Kirby must save his life with horror trivia questions, a callback to Casey Becker (Drew Barrymore), also in the original scene, now taking place in the tentative climax. She mentions Psycho (1960) as starting the slasher craze, but the killer states it is Peeping Tom (1960), the first film to "put the audience in the killer's POV." She begs for one more question to save Charlie's life. After answering every remake she can think of, Ghostface goes silent, making her assume she has won the trivia game.