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L-694247
L-694247 is a selective serotonin 5-HT1B and 5-HT1D full agonist, with similar affinities and activational potencies at these two receptors, about 20- to 25-fold greater affinity for the serotonin 5-HT1D receptor over the serotonin 5-HT1A receptor, and negligible affinity for the serotonin 5-HT1E and 5-HT1F receptors.
When L-694247 was injected intraventricularly in dehydrated rats, it inhibited water intake. Pre-treatment with a serotonin 5-HT1D antagonist abolished this effect. Administration of L-694,247 to normally hydrated rats had no effect on water intake.
L-694247 is a 5-substituted tryptamine derivative.
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L-694247
L-694247 is a selective serotonin 5-HT1B and 5-HT1D full agonist, with similar affinities and activational potencies at these two receptors, about 20- to 25-fold greater affinity for the serotonin 5-HT1D receptor over the serotonin 5-HT1A receptor, and negligible affinity for the serotonin 5-HT1E and 5-HT1F receptors.
When L-694247 was injected intraventricularly in dehydrated rats, it inhibited water intake. Pre-treatment with a serotonin 5-HT1D antagonist abolished this effect. Administration of L-694,247 to normally hydrated rats had no effect on water intake.
L-694247 is a 5-substituted tryptamine derivative.