This is a list of space probes that have left Earth orbit (or were launched with that intention but failed), organized by their planned destination. It includes planetary probes, solar probes, and probes to asteroids and comets. Flybys (such as gravity assists) that were incidental to the main purpose of the mission are also included.

Excluded are lunar missions, which are listed separately at List of lunar probes and List of Apollo missions. Flybys of Earth are listed separately at List of Earth flybys. Planned and proposed missions are in the List of proposed Solar System probes.

Colour key:

While the Sun is not physically explorable with current technology, the following solar observation probes have been designed and launched to operate in heliocentric orbit or at one of the Earth–Sun Lagrangian points – additional solar observatories were placed in Earth orbit and are not included in this list:

Early programs encompassing multiple spacecraft include:

In addition, several planetary probes have sent back observations of the Earth-Moon system shortly after launch, most notably Mariner 10, Pioneers 10 and 11 and both Voyager probes (Voyager 1 and Voyager 2).

Major early programs encompassing multiple probes include:

For completeness, this section lists probes that have left (or will leave) Earth orbit, but are not primarily targeted at any of the above bodies.