Luzerne County is a home rule county in the Commonwealth of Pennsylvania. According to the United States Census Bureau, the county has a total area of 906 square miles (2,350 km²), of which 890 square miles (2,300 km²) is land and 16 square miles (41 km²) is water. It is Northeastern Pennsylvania's second-largest county by total area. As of the 2020 census, the population was 325,594, making it the most populous county in the northeastern part of the state. The county seat and most populous city is Wilkes-Barre. Other populous communities include Hazleton, Kingston, Nanticoke, and Pittston. Luzerne County is included in the Scranton–Wilkes-Barre–Hazleton Metropolitan Statistical Area, which has a total population of 555,426 as of 2017. The county is part of the Northeast region of the commonwealth.

On September 25, 1786, Luzerne County was formed from part of Northumberland County. It was named after Chevalier de la Luzerne, a French soldier and diplomat during the 18th century. When it was founded, Luzerne County occupied a large portion of Northeastern Pennsylvania. From 1810 to 1878, it was divided into several smaller counties. The counties of Bradford, Lackawanna, Susquehanna, and Wyoming were all formed from parts of Luzerne County.

The county gained prominence in the 19th and 20th centuries as an active anthracite coal mining region, drawing a large portion of its labor force from European immigrants. At its peak in 1930, the county's population was 445,109. Many factories and coal mines closed by the early 21st century. Like most regions in the Rust Belt, Luzerne County witnessed population loss and urban decay. However, in recent years, the economy has grown moderately; warehousing has replaced manufacturing as the main industry.

The Luzerne County Historical Society maintains the storehouse for the collective memory of Luzerne County and its environs. It records and interprets the history, traditions, events, people, and cultures that have directed and molded life within the region.

Long an area occupied by indigenous peoples, by the 1700s the Wyoming Valley was inhabited by several Native American tribes including the Susquehannock, who spoke an Iroquoian language, and the Delaware (Lenape), who spoke an Algonquian language. In the mid-18th century, Connecticut settlers of primarily English ancestry ventured into the valley. These were the first recorded Europeans in the region. Some came as missionaries to the Native American peoples, while others came to farm the fertile land near the Susquehanna River. Ultimately, the violence of the French and Indian War (the North American front of the Seven Years' War between Great Britain and France) drove these Connecticut settlers away.

The British colonies of Pennsylvania and Connecticut both claimed the Wyoming Valley as their own. King Charles II of England had granted the land to the Connecticut Colony in 1662, but also to William Penn, the founder of Pennsylvania, in 1681. In 1769, Yankee settlers from Connecticut returned to the valley and founded the town of Wilkes-Barre. However, they were not alone. Pennsylvanian settlers (Pennamites) were also in the region.

Armed bands of Pennamites harassed the Connecticut settlers in what is known as the Pennamite-Yankee Wars. While the land dispute continued, a much larger conflict began. In 1775, the Thirteen Colonies began a war of independence against Great Britain. Residents of both Pennsylvania and Connecticut were largely loyal to the Patriot cause, which supported the American Revolution and independence.

On June 30, 1778, Loyalist forces, under the command of Major John Butler, arrived in the Wyoming Valley to attack the rebel American settlements. On July 1, Fort Wintermoot at the north end of the valley surrendered without a shot being fired. The next morning the smaller Fort Jenkins surrendered. Both forts were later burned to the ground.