The MTV Video Music Award for Best Collaboration was first introduced to the MTV Video Music Awards in 2007 under the name Most Earthshattering Collaboration, as the VMAs were revamped and a few new categories were added to the show. When MTV brought the VMAs back to their old format in 2008, this category did not return. It was not until 2010 that the category was reintroduced under the name Best Collaboration.

Beyoncé, Lady Gaga and Taylor Swift have received the most wins in this category with three moonmen each. Beyoncé won for "Beautiful Liar" with Shakira (2007), "Telephone" with Lady Gaga (2010) and "Drunk in Love" with Jay-Z (2014). Taylor Swift won for "Bad Blood" with Kendrick Lamar (2015), "I Don't Wanna Live Forever" with Zayn (2017) and "Fortnight" (2024) with Post Malone. Lady Gaga and Shakira have each won in this category 2 times - Lady Gaga for "Telephone" with Beyoncé (2010) and "Rain on Me" with Ariana Grande (2020), and Shakira for "Beautiful Liar" with Beyoncé (2007) and "TQG" with Karol G (2023).

Rihanna, Ariana Grande and Drake are the most nominated artists with six nominations, followed by Beyoncé, Lady Gaga and Post Malone with five nominations.