The Macy conferences were a set of meetings of scholars from various academic disciplines held in New York under the direction of Frank Fremont-Smith at the Josiah Macy Jr. Foundation starting in 1941 and ending in 1960. The explicit aim of the conferences was to promote meaningful communication across scientific disciplines, and restore unity to science. There were different sets of conferences designed to cover specific topics, for a total of 160 conferences over the 19 years this program was active; the phrase "Macy conference" does not apply only to those on cybernetics, although it is sometimes used that way informally by those familiar only with that set of events. Disciplinary isolation within medicine was viewed as particularly problematic by the Macy Foundation, and given that their mandate was to aid medical research, they decided to do something about it. Thus other topics covered in different sets of conferences included: aging, adrenal cortex, biological antioxidants, blood clotting, blood pressure, connective tissues, infancy and childhood, liver injury, metabolic interrelations, nerve impulse, problems of consciousness, and renal function.

The Josiah Macy, Jr. Foundation developed two innovations specifically designed to encourage and facilitate interdisciplinary and multidisciplinary exchanges; one was oral: the Macy conferences, and one was written: the Macy transactions (published transcriptions of the conferences). Macy conferences were essentially conversations held in a conference setting, with participants presenting research while it was still in process (rather than after it had been completed). These were more formal than conversations (papers were prepared ahead of time and circulated) but less formal than conferences. Macy transactions were transcriptions widely circulated to those who could not attend. These were far more informal than typical proceedings, which publish revised versions of conference papers, and served to invite additional scholars into the exchange. The explicit goal was to let a wider audience hear the experts exchange ideas and think out loud about their own work. But even participants themselves found the transactions valuable, as a way to prompt memories, and to catch comments they might have missed. A few comments were made explicitly referring to later publication of the conference discussions, so clearly participants took this into account. However, Fremont-Smith explicitly stated that actual discussion should always take priority.

Participants were leading scientists from a wide range of fields. Casual recollections of several participants as well as published comments in the Transactions volumes stress the communicative difficulties in the beginning of each set of conferences, giving way to the gradual establishment of a common language powerful enough to communicate the intricacies of the various fields of expertise present. Participants were deliberately chosen for their willingness to engage in interdisciplinary conversations, or for having formal training in multiple disciplines, and many brought relevant past experiences (gained either from earlier Macy conferences or other venues). As participants became more secure in their ability to understand one another over the course of a set of conferences on a single topic, their willingness to think outside their own specializations meant that creativity increased.

The Macy Cybernetics Conferences were preceded by the Cerebral Inhibition Meeting, organized by Frank Fremont-Smith and Lawrence K. Frank, and held on 13–15 May 1942. Those invited were Gregory Bateson, Frank Beach, Carl Binger, Felix Deutsch, Flanders Dunbar, Julie Eisenbud, Carlyla Jacobsen, Lawrence Kubie, Jules Masserman, Margaret Mead, Warren McCulloch, Bela Mittelmann, David Rapoport, Arturo Rosenblueth, Donald Sheehan, Georg Soule, Robert White, John Whitehorn, and Harold Wolff. There were two topics:

The Cybernetics conferences were held between 1946 and 1953, organized by the Josiah Macy, Jr. Foundation, motivated by Lawrence K. Frank and Frank Fremont-Smith of the Foundation. As chair of this set of conferences, Warren McCulloch had responsibility to ensure that disciplinary boundaries were crossed. The Cybernetics were particularly complex as a result of bringing together the most diverse group of participants of any of the Macy conferences, so they were the most difficult to organize and maintain.

The principal purpose of these series of conferences was to set the foundations for a general science of the workings of the human mind. These were one of the first organized studies of interdisciplinarity, spawning breakthroughs in systems theory, cybernetics, and what later became known as cognitive science.^{[citation needed]}

One of the topics spanning a majority of the conferences was reflexivity. Claude Shannon, one of the attendees, had previously worked on information theory and laid one of the initial frameworks for the Cybernetic Conferences by postulating information as a probabilistic element which reduced the uncertainty from a set of choices (i.e. being told a statement is true, or even false, completely reduces the ambiguity of its message).

Other conference members, especially Donald MacKay, sought to reconcile Shannon's view of information, which they called selective information, with theirs of 'structural' information which signified how selective information was to be understood  (i.e. a true statement might acquire additional meanings in varied settings though the information exchanged itself has not changed). The addition of meaning into the concept of information necessarily brought the role of the observer into the Macy Conferences. MacKay argued that by receiving and interpreting a message, the observer and the information they perceived ceased to exist independently of one another. The individual reading and processing the information does so relative to their preexisting internal state, consisting of what they already know and have experienced, and only then acts.