Magical Starsign, originally released in Japan as Magical Vacation: When the Five Stars Align, is a role-playing video game for the Nintendo DS developed by Brownie Brown. It is the sequel to the Japan-exclusive Game Boy Advance title, Magical Vacation. It was released in Japan and the United States in 2006 and was released in Europe the next year. Nintendo Australia did not publish the game in Australia and New Zealand as it expected low sales of the game.^{[citation needed]}

The player uses the Nintendo DS's touch screen for character control and interaction, while the top screen displays maps and other general information. The battle system is turn-based, and the position of the planets within the game affects the amount of damage wielded or received by each character. All characters in the game are associated with a specific planet, and their magic attack power is boosted when a character's planet is positioned favorably. Players can also boost their attack power by tapping their character when the circle of symbols has disappeared around them during a battle. This is known as a "Spell Strike", and a large flash of color (the same color assigned to the character's element) appears prior to the attack. The player may also tap their character right before they are hit with an attack to receive less damage. This is known as a "Reflex Guard" and puts the character into a guard stance and causes them to glow with blue light. However, some attacks cannot be guarded against in this way.

There are 7 different elements in the game (light, darkness, fire, water, wood, earth, and wind) which each correspond to a planet in the game's planetary system. The Astrolog tracks the movement of these planets, which move clockwise around a central point as time passes within the game. The orbital velocity of each planet varies according to their size and location. Magic spells of certain elements are twice as effective while a planet is orbiting within the area assigned to its corresponding element. This bonus applies for both the player's magic spells and enemy spells. The light and dark elements are instead affected by solar activity: light magic is more powerful during the daytime, and dark magic is more powerful during the night (in-game time is viewable as an animated hourglass). A certain spell acquired later in the game allows the player to move the planets to an advantageous position; or potentially align the 5 planets in a straight line (as indicated in the Japanese version's subtitle), which causes far more damage than the standard elemental bonus. The planets may also happen to align without using the spell, but this causes damage to both the player and the enemy.

Up to six players may connect locally (a game card is required for each player), taking their characters into a dungeon where they work together to defeat monsters while racing to collect treasure. Points are awarded for damage done to enemies and treasure collected from chests, and the player with the most points at the end wins the multiplayer mode. Experience points and treasures gained in this mode are applied to the main game.

Tag mode allows players to exchange game data to gain new items. Up to 100 players are recorded on the game's friend list, and the item gained will vary depending on in-game progress or the main character's element. There is also an option to create a short message displayed when tag mode is used, allowing players to exchange messages with each other. Using the tag mode frequently will create an "egg character", which becomes stronger each time tag mode is used successfully. The player can use the egg character in the main game, but it will not gain levels with experience like other characters.

Magical Starsign takes place in the fantasy world of the Baklava solar system, a planetary system composed of six planets that orbit a sun. The five closest planets to the sun each represent a different magical attribute, also known as a starsign, and host vastly different landscapes and civilizations: Razen (fire), Gren (wood), Puffoon (wind), Cassia (water), and Erd (earth). The sixth and most remote planet, Kovomaka, is home to Kovomaka Kingdom and Will-o’-Wisp Academy, a school headed by Principal Biscotti where aspiring sorcerers are taught magic.

The player controls six apprentice magicians in Magical Starsign: Lassi, a scatterbrained rabbit from an immigrant community who uses wind magic; Mokka, a deadpan ancient robot who uses earth magic; Chai, a salamander with the rare ability to use wood magic; Pico, a hot-blooded ōendan who uses fire magic; Sorbet, the academy's top student from a destitute family who uses water magic; and the player-named protagonist, who can be assigned either light or dark magic. They are all enrolled in Will-o'-Wisp's Class B, mentored by the capricious yet powerful sorceress Miss Madeleine. The primary antagonist of the game is Master Kale, an old student of Madeleine who, leading a band of astro pirates, plots to destroy the Baklava system by fulfilling an apocalyptic prophecy.

The students overhear Principal Biscotti ordering Miss Madeleine to travel to Puffoon and confront Kale, whose pirates have been causing trouble across Baklava. Three months go by and Madeleine has made no contact with the academy, which pushes Lassi to find her using the academy's secret stash of rockets. Her classmates give chase, getting scattered across Baklava in the process. The protagonist reunites with Lassi on Erd, teaming up to procure a new rocket capable of interplanetary travel. On their journey to find the other students, they make enemies with Kale's accomplice Chard and his pirates, who have taken Madeleine to Razen. They eventually discover that Madeleine, among many other magicians, was arrested by Puffoon's Space Police. Upon reaching Razen, the group accidentally foil Sorbet's plan to save Madeleine by pretending to cooperate with Kale, who uses a spell to teleport his crew and the magicians he abducted into the sun.