Maryland wine is wine made in the U.S. state of Maryland. The industry has grown rapidly since the first winery in Maryland, Boordy Vineyards, opened in 1945. It is estimated that the industry contributes $50 million annually to the Maryland economy.

The state's history of viticulture begins in 1648 with the earliest recorded instance of winemaking in Maryland. Fourteen years later, the first European grapes planted in Maryland were deposited in 200 acres (80.9 ha) on the east bank of St. Marys River. It was not until the 1930s that Philip Wagner, a columnist with the Baltimore Sun, published American Wines and How to Make Them. The book was later revised as Grapes Into Wine and became the definitive book on winemaking in America.

The 1980s proved to be a definitive decade for the industry. In 1981, the Maryland Grape Growers Association was formed, followed by the Maryland Wineries Association in 1984. That same year, the Maryland Wine Festival was held for the first time and the Maryland Winery and Grape Growers Advisory Board was formed.

In 2000, the Maryland State Legislature passed Maryland House Bill 414, allowing state wineries to sell wine by the glass at the winery and to bring product onto retail licensed premises for promotional activities. A record crowd of more than 25,000 attended the Maryland Wine Festival and Maryland wineries sold a record 86,954 US gallons (329,157 L) of wine.

Throughout the years that followed, the industry saw many changes as well as growing success. The instigator of such success was the Maryland Wineries Association's first-ever major cooperative marketing campaign, "Ask For Maryland Wine."

Maryland has four distinct growing regions, allowing for a wide diversity of grape varieties that will thrive throughout the State.

A majority of the state's vineyards are planted in Central Maryland, from the foothills west of Frederick, Maryland to the head of the Chesapeake Bay. The state's oldest wineries are located in the Piedmont Plateau as well as the Frederick Wine Trail and Mason-Dixon Wine Trail. There are clusters of wineries around Westminster and north of Baltimore. Cabernet Sauvignon, Merlot, Cabernet Franc, Chardonnay and Pinot Gris are planted, which consists of Harford, Baltimore, Carroll, Howard, Montgomery and Frederick Counties.

The Eastern Shore is known for its warm days and cool nights. The soil is sandy and well-drained, and the climate is moderated by the Chesapeake Bay. A wide variety of grapes are growing throughout the Upper Shore (Cecil, Kent and Queen Anne's Counties), Mid Shore (Talbot, Dorchester and Caroline Counties) and Lower Shore (Somerset, Worcester and Wicomico Counties).