Megatominae is a subfamily of the beetle family Dermestidae. This subfamily contains several of the most well-known household and stored-product pest beetles, in the genera Anthrenus and Trogoderma.

According to World Dermestidae catalogue (Jiří Háva, 2023), following taxonomic division is proposed for Megatominae:

The genera listed below currently belong to subfamily Megatominae (subtribes omitted)

Anthrenini:

Ctesiini:

Megatomini: