Mezzo DSA is a 13-episode anime series created by Yasuomi Umetsu and the first not to be licensed by Anime Works, but instead licensed by ADV Films. It is a follow-up to the 2001 OVA Mezzo Forte.

Mikura, Kurokawa, and Harada are the three members of the Danger Service Agency (DSA). Mikura is the brawn of the group, Harada is the brains, and Kurokawa is just a bitter ex-cop who likes to think he's in charge. They'll take on any job as long as it involves much danger and, of course, money. Their biggest case, however, could prove to be finding out why someone wants Kurokawa assassinated.

The DSA's headquarters is an old red British double-decker bus that has been converted into living quarters for the three main characters. It has been placed on the rooftop of a two-story building which houses Mugiyama's barber shop on the ground floor. They drive an old-style pink Volkswagen Beetle.

The series concerns three characters who comprise the Danger Service Agency (D.S.A.), as well as a young acquaintance of theirs. The main characters include:

There is also a selection of minor characters in the series, some of which even have major significance with the major ones.

A manga adaptation (which had the full title, Mezzo Danger Service Agency) which covered all 13 episodes in 1 tankobõn volume, was released in April 2004, a month after the anime ended. It has currently not been licensed or translated by any American company.

The opening theme is "「スキマミマイタイ」 Suki Mami Mai Tai" by Barnabys (Shoko, Ai & Miyo) while the ending theme is 蜜 (Mitsu, lit. Honey) by Barnabys.