Milton Slocum Latham (May 23, 1827 – March 4, 1882) was an American politician, who served as the sixth governor of California and as a U.S. representative and U.S. senator. Latham holds the distinction of having the shortest governorship in California history, lasting for five days between January 9 and January 14, 1860. A Lecompton Democrat, Latham resigned from office (the second governor to do so) after being elected by the state legislature to a seat in the U.S. Senate.

Born in Columbus, Ohio in 1827, Latham was educated in classical studies at Jefferson College in Washington, Pennsylvania, graduating in 1845. Following his graduation, Latham moved to Russell County, Alabama, working briefly as a school teacher while studying law. He was admitted to the Alabama State Bar in 1848, working as Russell County's circuit court clerk for two years until 1850, when he relocated to San Francisco, California following the Gold Rush.

In San Francisco, Latham continued in law, becoming a recording clerk for the county, and in 1851, the district attorney of Sacramento. After serving for one year, Latham entered politics, and in 1852, ran as a Democrat and won a seat in the U.S. House of Representatives. After the completion of his two-year term, Latham declined to run for another term and returned to California to again practice law, despite being renominated by state Democrats.

Only a year after returning to San Francisco, Latham was appointed U.S. Customs Collector for the Port of San Francisco by President Franklin Pierce, a post the former congressman protested initially, but reluctantly later accepted. Latham held the post until 1857.

Since the beginning of the 1850s, issues regarding slavery had effectively split the national Democratic Party. California was controlled by the states-rights Chivalry wing, who had defeated Tammany Hall in the state. Nationally, by 1857, the party had split into the Lecompton and Anti-Lecompton factions. Lecompton members supported the Kansas Lecompton Constitution, a document explicitly allowing slavery into the territory, while Anti-Lecompton faction members were in opposition to slavery's expansion. The violence between supporting and opposition forces led to the period known as Bleeding Kansas. Splits in the Democratic Party, as well as the power vacuum created by the collapse of the Whig Party, helped facilitate the rise of the American Party both in state and federal politics. In particular, state voters voted Know-Nothings into the California State Legislature, and elected J. Neely Johnson as governor in the 1855 general elections.

During the 1859 general elections, Lecompton Democrats voted Latham, who had briefly lived in the American South, as their nominee for governor. Anti-Lecomptons in turn selected John Currey as their nominee. The infant Republican Party, running in its first gubernatorial election, selected businessman Leland Stanford as its nominee. To make matters more complicated, during the campaign, Senator David C. Broderick, an Anti-Lecompton Democrat, was killed in a duel by slavery supporter and former state Supreme Court Justice David Terry on September 13.

Despite the party split and Republican entrance to the campaign, Latham won the election, garnering sixty percent of the vote.

Latham was inaugurated on January 9, 1860. In his inauguration speech, the new governor outlined his main priority as solving the state's creeping debt, an issue that previously challenged former governors John Bigler, J. Neely Johnson and John Weller. Latham suggested curtailing legislative expenses, erecting more governmental buildings—such as completing the new State Capitol building—without raising taxes, and increasing U.S. Mail links from the Eastern United States to California to help facilitate commerce and personal links. Latham also suggested that the Office of the governor should not be made more powerful, and be securely checked by the legislature and courts.