Nora's initial cryogenic suspension represents Mr. Freeze's desperate attempt to preserve her life until a cure for her illness can be found. This act becomes the central focus of his existence and the driving force behind his criminal activities.

Throughout his history, there have been instances where a potential cure for Nora's condition is discovered, or she is temporarily revived. These moments offer Mr. Freeze a glimmer of hope, but they are often short-lived and followed by further tragedy.

In some storylines, Nora ultimately succumbs to her illness, or her cryogenic suspension fails, leading to her death. This event shatters Mr. Freeze's already fragile psyche, pushing him further into despair and fueling his desire for revenge against those he blames for her demise.

In some continuities, Nora is revived and empowered with abilities similar to Mr. Freeze's. She may become an ally or an adversary, challenging his perception of her and forcing him to confront his own actions. This could also involve her being corrupted or manipulated, further complicating their relationship.