Mr. Freeze sometimes forms temporary alliances with other villains to achieve a specific goal, such as robbing a bank, escaping from prison, or taking down Batman. These alliances are often based on mutual benefit and are rarely characterized by genuine trust or loyalty.

The criminal underworld of Gotham City is rife with betrayal, and Mr. Freeze is not immune to being double-crossed or betrayed by his fellow villains. These experiences reinforce his cynicism and isolation, making him even more reluctant to trust others.

Mr. Freeze often finds himself in conflict with other villains over territory, resources, or competing criminal schemes. These rivalries can escalate into violent confrontations, adding to the chaos and danger of Gotham City.

Characters such as Poison Ivy or Clayface may have unique sympathies for Victor as he can be viewed as one of the 'Freaks'. These connections allow him to be more aligned with certain villains than with others.