Mughallis (Arabic: مٌغلّس) was a Palestinian Arab village located 30.5 kilometers (19.0 mi) northwest of Hebron. It was depopulated during the 1948 Arab-Israeli War between July 9–10, 1948 as part of Operation An-Far.

It was incorporated into the Ottoman Empire in 1517 with the rest of Palestine, and by the 1596 tax records it was located it nahiya (subdistrict) of Gaza, part of Gaza Sanjak, with a population of 77 household, an estimated 424 persons, all Muslims. The villagers paid a fixed tax-rate of 25% on agricultural products, including wheat, barley, summer crops, fruit trees, goats and beehives, in addition to occasional revenues; a total of 10,350 akçe. All of the revenue went to a Waqf.

In May 1863 Victor Guérin described it as a hamlet, still inhabited by a few families, and was designated to him by the name of Deir al Mokhalles, which Guérin translated as the Convent of the Saviour. He noted that the name probably derived from a former convent, which formerly existed at the place.

An Ottoman village list of about 1870 showed that Meghallis had 27 houses and a population of 71, though the population count included men, only.

In 1882, the PEF's Survey of Western Palestine (SWP) described Mughullis as: "A village of moderate size, approached by an ancient road, and principally consisting of stone houses."

In the 1922 census of Palestine, conducted by the British Mandate for Palestine, the population was recorded as 311 Muslims, increasing in the 1931 census to 447 Muslims, in 93 houses.

In the 1945 statistics it had a population of 540 Muslims, with 11,459 dunams of land. 88 dunams were plantations and irrigable land, 7,277 for cereals, while 23 dunams were built-up (urban) land.

Mughallis became depopulated on July 9–10, 1948. On 16 July, Giv‘ati HQ informed General Staff\Operations that "our forces have entered the villages of Qazaza, Kheima, Jilya, ‘Idnibba and Mughallis, expelled the inhabitants, [and] blown up and torched a number of houses. The area is at the moment clear of Arabs."