NFL on NBC is an American television sports presentation show broadcast by NBC. It aired from October 22, 1939 to January 25, 1998. The show returned on August 6, 2006. The branding is used for the presentation of the National Football League (NFL). It is the longest running American TV show.

NBC had sporadically carried NFL games as early as 1939, including the championship and Pro Bowl through the 1950s and early 1960s. Beginning in 1965, NBC signed an agreement to carry the American Football League (AFL)'s telecasts, which carried over with the American Football Conference (AFC) when the AFL merged with the NFL. NBC would continuously carry the AFL/AFC's Sunday afternoon games from 1965 through the 1997 season, after which NBC lost the AFC contract to CBS.

NBC's current flagship NFL program, NBC Sunday Night Football, began airing on NBC in 2006. Alongside Sunday Night Football, NBC airs the annual preseason Pro Football Hall of Fame Game, the NFL Kickoff game, the primetime game on Thanksgiving Day, and one regular season game on Peacock. During the NFL Playoffs, NBC airs one to three Wild Card Playoff games with one guaranteed on a Sunday night, one Divisional Round Playoff game, and the Super Bowl in rotation with Fox, CBS and ESPN/ABC. In 2024, NBC aired a third Wild Card Playoff game on Peacock. From 2016 to 2017, NBC added a five-game Thursday Night Football package to its offerings supplementing the NFL Kickoff and Thanksgiving Day Thursday night games that were already part of NBC's coverage. Game coverage is usually preceded by the pregame show Football Night in America.

NBC's coverage of the National Football League (which has aired under numerous program titles and formats) actually goes back to the beginnings of the network's relationship with the league in 1939, when its New York City flagship station, then known as W2XBS (now WNBC) aired the first televised professional football game between the Philadelphia Eagles and the now-defunct Brooklyn Dodgers football team. Even before this, in 1934, NBC Radio's Blue Network had carried the Detroit Lions' inaugural Thanksgiving game nationwide.

By 1955, NBC became the television home to the NFL championship game, the precursor to the Super Bowl, paying US$100,000 to the league for the rights. The network had taken over the broadcast rights from the DuMont Television Network, which had struggled to give the league a national audience (NBC's coverage of proto-Canadian Football League games from the year prior was more widely available at the time) and was on the brink of failure; the NFL's associations with NBC (as well as with CBS) proved to be a boost to the league's popularity. For the 1957 NFL championship game, Van Patrick and Ken Coleman split a half of the play-by-play duties and Red Grange, normally on play-by-play for Chicago Bears games on CBS, assumed the color commentator role for this game. The 1958 NFL championship game, played at Yankee Stadium, between the Baltimore Colts and the New York Giants went into sudden death overtime. This game, since known as the "Greatest Game Ever Played", was seen by many throughout the country and is credited with increasing the popularity of professional football in the late 1950s and early 1960s. Chris Schenkel called the first half while Chuck Thompson called the second half and overtime.

NBC televised the NFL championship game until 1963. The contract for the title game was separate than the regular season contracts held by CBS, which started televising NFL games in 1956. Prior to 1962, each team had its own individual television contract. (This was in contrast to the American Football League as well as established practice in college football, both of which forced all of their members to participate in a collective television contract. As the legality of such a collective contract was still in question at the time, and would eventually be declared illegal in 1984, the NFL did not pursue such a contract until Congress explicitly allowed for the NFL to do so, with conditions, in the Sports Broadcasting Act of 1961.) NBC held individual team contracts with the Pittsburgh Steelers and Baltimore Colts in 1959, 1960 and 1961. While the games were blacked out in Pittsburgh and Baltimore, they were broadcast on other NBC stations. In some cases, the game broadcast was seen on CBS in the visiting team's home region. NBC covered eleven games in 1960 and 13 games in 1961 in a "Game of the Week" format. NBC would take one week off due to its coverage of the World Series. During this era, NBC broadcast pre-recorded and edited hour-long broadcasts of NFL games in the off-season under the title Best of Pro Football.

During this period, NBC also held the rights to the Pro Bowl (which was also under a separate contract from the NFL's regular season games and the NFL championship game) via the Los Angeles newspapers' charities. NBC televised the Pro Bowl following the 1951 and 1952 seasons and again from the 1957 to 1964 seasons. The 1957 game was offered to NBC, then CBS. Both declined to carry the game. ABC was then offered to televise and accepted, but could not gain enough clearance of affiliates in time to make it a profitable venture. Thus they also dropped out and the game was not televised.

At the start of the 1960s, 10 of the NFL's 13 NFL teams (including the brand new Dallas Cowboys) were aligned with CBS, two joined forces with NBC (the aforementioned Colts and the Steelers) and one (the Cleveland Browns) rejoined its partner, the syndicated Sports Network. NBC during this time period, employed Lindsey Nelson and Frankie Albert as their top broadcasting crew.