Northern Michigan (also known as Northern Lower Michigan and colloquially within Michigan as "Up North") is a region of the U.S. state of Michigan. The region, which is distinct from the more northerly Upper Peninsula and Isle Royale, which are also located in the north of the state, is bounded to the west by Lake Michigan, and to the east by Lake Huron. The Upper Peninsula is accessible from the region via the Mackinac Bridge. While the region's southern boundary is not precisely defined, most definitions include the northernmost 21 counties of the Lower Peninsula, which had a population of 506,658 people at the 2020 census. Its largest cities are Traverse City, Cadillac, Alpena, Ludington, Manistee, and Petoskey.

Like the Upper Peninsula, Northern Michigan is a popular tourist destination, and is more rural than the rest of the state. The region is home to several small- to medium-sized cities, extensive state and national forests, lakes and rivers, and a large portion of Great Lakes shoreline. The region has a significant seasonal population much like other regions that depend on tourism as a primary industry.

For thousands of years before the French and English set up colonies in the region, Northern Michigan was inhabited by Native American cultures and succeeding tribes. Northern Michigan was the southern extent of the area scholars believed occupied by prehistoric inhabitants known as the Laurel complex. They were part of the Hopewell Indian exchange system, which is named after a prehistoric tribe that existed in the Great Lakes region.

According to Menominee tradition, this tribe's original homeland was farther north, near present-day Sault Ste. Marie and Michilimackinac. At some period before European contact (probably around 1600), they were forced southwest to the Menominee River by arrival of the Ojibwe, Odawa, and Potawatomi from the east. Odawa history written by Andrew Blackbird records that Emmet County was thickly populated by a race of Indians that they called the Mush-co-desh, which means "the prairie tribe". The Mush-co-desh had an agrarian society and were said to have "shaped the land by making the woodland into prairie as they abandoned their old worn out gardens which formed grassy plains". Ottawa tradition claims that they slaughtered from forty to fifty thousand Mush-co-desh and drove the rest from the land after the Mush-co-desh insulted an Ottawa war party. Previous to the Mush-co-desh, the areas surrounding the Straits of Mackinac, was home to the Michinemackinawgo. Originally known as the Mishiiken Tribe, their summer land was Mackinac Island and their surrounding lands were referred to as Mishiiken-imakinakom. These lands included wintering grounds in the hills on the south side of Little Traverse Bay. The Mishiiken were a race of natives of small stature that were nearly wiped out by the Iroquois in the 1640s during the Beaver Wars. The remnants of this race were taken in by the Ojibwe and still exist today amongst the Mackinac Bands of Chippewa and Ottawa Indians.

In the historic period, the Anishinaabe/Algonquian-speaking peoples known as the Ojibwe, Odawa and Potawatomi, formed a loose confederation which they called the Council of Three Fires. They inhabited areas surrounding the Straits of Mackinac, the upper and lower peninsulas of Michigan, and the northern islands and shoreline of Canada along Lake Huron.

In 1608, Samuel de Champlain established Quebec as part of New France. He sent coureur des bois such as Étienne Brûlé into the woods to establish relations with the Indians. Around 1615 or 1616, Champlain traveled to Georgian Bay via the French River and met Ottawa and Huron Indians on the south end near Penetanguishene. The French established the North American fur trade with Indian tribes. In the decades that followed, French explorers and missionaries continued to explore the "Upper Country" of New France that included the Upper Great Lakes. In 1634, Jean Nicolet passed through the straits of Mackinac on the way to Wisconsin. While France colonized the interior lands along the St. Lawrence River, the Dutch and English began colonizing the East Coast of North America, setting up fur trade and arming the Iroquois along the east and southeast of the Great Lakes. Competition for trade and pelts resulted in the brutal Beaver Wars. The Iroquois pushed west into the Great Lakes territory, displacing the tribes who had settled there before. As a result of an Iroquois attack and dispersal of the Huron from Southern Ontario in 1649, the Huron sought refuge with the Ojibwe at Michilimackinac where eventually a Jesuit mission was established for their care.

Jesuit Father Marquette set up a mission in St. Ignace in 1671. While the Beaver Wars raged on, Marquette evangelized the Indians. From May 17, 1673, until Marquette's death near Ludington on May 18, 1675, Father Marquette and Louis Jolliet explored and mapped Lake Michigan and the northern portion of the Mississippi River. In 1679, René-Robert Cavelier, Sieur de La Salle and Father Louis Hennepin set out on Le Griffon to find the Northwest Passage; it was the first known sailing ship to sail in Northern Michigan. They sailed across Lake Erie, Lake Huron, and Lake Michigan through uncharted waters, which previously only men in canoes had explored. After Marquette's death, the mission was taken over by Father Phillip Pierson, and then Father Nouvel.

Father Henri Nouvel was "Superior of the Otawa missions", Nouvel served in this position from 1672 to 1680 (with a two-year break in 1678–1679), and again from 1688 to 1695. Under Nouvel, a new chapel was built in approximately 1674. By 1683 the mission was so successful and prosperous that three priests, Fathers Nicholas Potier, Enjalran, and Pierre Bailloquet, were assigned there. The establishment of a French garrison at St. Ignace in 1679 disrupted relations between the French and the local population, as the soldiers were less educated and amiable than the missionaries.