Organology (/ˌɔːrɡəˈnɒlədʒi/; from Ancient Greek ὄργανον organon 'instrument' and λόγος logos 'the study of') is the science of musical instruments and their classifications. It embraces study of instruments' history, instruments used in different cultures, technical aspects of how instruments produce sound, and musical instrument classification. There is a degree of overlap between organology, ethnomusicology (being subsets of musicology) and the branch of the science of acoustics devoted to musical instruments.

A number of ancient cultures left documents detailing the musical instruments used and their role in society; these documents sometimes included a classification system. The first major documents on the subjects from the west, however, date from the 16th century, with works such as Sebastian Virdung's Musica getuscht und ausgezogen (1511), and Martin Agricola's Musica instrumentalis deudsch (1529).

One of the most important organologists of the 17th century is Michael Praetorius. His Syntagma musicum (1618) is one of the most quoted works from that time on the subject, and is the source of much of what we know about renaissance musical instruments. Praetorius's Theatrum instrumentorium (1620) contains possibly the first pictures of African instruments in a European publication.

For much of the 18th and 19th centuries, little work was done on organology. Explorers returned to Europe with instruments from different cultures, however, so that by the end of the 19th century, some musical instrument collections were quite large. This led to a renewed interest in the subject.

One of the most important organologists of the 20th century was Curt Sachs, who, as well as writing Real-Lexicon der Musikinstrumente (1913) and The History of Musical Instruments (1940), devised with Erich von Hornbostel the Hornbostel–Sachs scheme of instrument classification, which was first published in 1914 in the Zeitschrift für Ethnologie. This system classified musical instruments into four distinct categories: idiophones, membranophones, chordophones, and aerophones. This system of classification was updated several times by Sachs and Hornbostel and still continues to be updated periodically. One update to the system was made by Sachs in 1940 through the addition of a 5th category: electrophones, a category encompassing instruments which produce music electronically. Sachs' 1940 book, The History of Musical Instruments, was meant to be a comprehensive compilation of descriptions of instruments from many cultures and their functions within their societies. The book is primarily divided into four chronological periods of instruments: early instruments, antiquity, the middle ages, and the modern occident. These periods are further subdivided into regions and then to significant time periods within those regions. Andre Schaeffner introduced a system based on state-of-matter of the sound-producing mechanism, giving rise to two top-level categories: solid (containing strings and percussion), and gas (containing woodwind and brass). With the invention of the hydraulophone, the physics-based organology has been expanded to use solid, liquid, and gas, wherein the top-level category is the state of matter of the material that makes the sound.

A number of societies exist dedicated to the study of musical instruments. Among the more prominent are the Galpin Society, based in the United Kingdom; the American Musical Instrument Society, based in the United States; and the Gesellschaft der Freunde alter Musikinstrumente, based in Switzerland.

According to one paper written by Henry M. Johnson published by the University of Oxford, “the universally used classification system established by musical instruments of Hornbostel and Sachs has become the paradigm of organology in many cultures”. Additionally, Eliot Bates states in a paper published in the Journal of the Society of Ethnomusicology that “The Hornbostel–Sachs system was not intended to classify the specificity of unique instruments, but rather to highlight commonalities across the world of instruments.”

Margaret Kartomi, professor and chairperson in the Department of Music at Monash University in Melbourne, approached the topic of musical instrument classification in 1990 with the intention of understanding how musical instruments are classified across cultures. This approach was justified by her observation that the concepts upon which an outside European researcher might classify musical instruments of a particular culture are likely different from the way that those native to the culture choose to classify their musical instruments. Her book emphasizes the complexity that underlies the process of classifying musical instruments, as the classification system is often shaped by “socially influenced or structured ideas or belief systems”.