Painted Bluff is a cliff overlooking the Tennessee River in Marshall County, Alabama that features over 130 individual prehistoric Native American pictographs and petroglyphs. Painted Bluff is located about 4 miles (6.4 km) downstream from the Guntersville Dam and is only accessible by boat. The bluff is divided into three levels: the low ledge along the river, a middle ledge above it, and a high ledge near the top of the cliff face. A small cave is located along the low ledge.

Due to the humid environment, open-air rock art sites are rare in the Southeastern United States. TVA archaeologist Erin Pritchard considers Painted bluff to be "one of, if not the, most significant open-air rock art occurrence[s]" in the region.

The bluff has been subject to graffiti from the earliest days of its discovery by European Americans, with the oldest graffiti dating to the nineteenth century.

Painted Bluff is protected by the Archaeological Resources Protection Act of 1979, meaning that damaging or destroying any property is considered a felony.

Painted Bluff is a rocky outcropping of limestone that overlooks the Tennessee River. The carboniferous limestone that comprises the bluff formed between 359 and 323 million years ago, predating the formation of the North American contentment. It is mainly composed of Bangor Limestone.

Painted Bluff was inhabited by humans throughout the Woodland period into the Mississippian period, from about 800 BC to 1500 AD.

The first written references to Painted Bluff are from the nineteenth-century jurist and historian John Haywood in his 1823 book The Natural and Aboriginal History of Tennessee. Haywood moved to Nashville, Tennessee from his home state of North Carolina in 1807 and became fascinated by the prehistoric artifacts and monuments in the region. He believed that these artifacts and monuments were left by one of the Lost Tribes of Israel.

In 1959, the rock art of Painted Bluff was the subject of one of the first chemical analyses on rock art pigment ever published.